From the FDA Drug Label
Oropharyngeal candidiasis: The recommended dosage of fluconazole tablets for oropharyngeal candidiasis in children is 6 mg/kg on the first day, followed by 3 mg/kg once daily. Treatment should be administered for at least 2 weeks to decrease the likelihood of relapse The recommended treatment for oral candidiasis (thrush) in a 14-month-old infant is 6 mg/kg of fluconazole on the first day, followed by 3 mg/kg once daily for at least 2 weeks 1.
From the Research
For treating oral candidiasis in a 14-month-old child, fluconazole suspension is the most effective treatment, administered as 3 mg/kg in a single daily dose for 7 days, as it has been shown to be superior to nystatin suspension in achieving clinical cures 2. The treatment of oral candidiasis, also known as thrush, in infants is crucial to prevent discomfort during feeding and promote recovery.
- The most recent and highest quality study available is from 2002, which compared fluconazole and nystatin oral suspensions for the treatment of oral candidiasis in infants 2.
- The study found that fluconazole was superior to nystatin suspension, with a clinical cure rate of 100% compared to 32% for nystatin 2.
- Other studies have also discussed the treatment of oral candidiasis, including the use of nystatin, miconazole, and other antifungal drugs 3, 4, 5, 6.
- However, the 2002 study provides the most direct and relevant evidence for the treatment of oral candidiasis in infants, and its findings should be prioritized in clinical decision-making.
- In addition to antifungal treatment, good oral hygiene is essential to prevent the spread of the infection and promote recovery.
- Parents should be advised to clean the child's mouth with a soft cloth after feedings and sterilize pacifiers, bottles, and toys that go in the mouth.
- If the child is breastfeeding and the mother has nipple candidiasis, both should be treated simultaneously to prevent reinfection.