Dilution for 0.3mg/kg/hr Rate
For a 0.3mg/kg/hr rate, dilute the medication in distilled water at a concentration of 0.6mg/mL (or 600mcg/mL), which allows for a standard infusion rate of 0.5mL/kg/hr.
Calculation Method
When preparing continuous infusions, the concentration should be calculated based on:
- The desired dose rate (mg/kg/hr)
- The desired fluid administration rate (mL/kg/hr)
Step-by-Step Approach:
- Calculate the concentration by dividing the dose rate by the desired fluid rate 1
- For a 0.3mg/kg/hr dose rate with a standard infusion rate of 0.5mL/kg/hr:
- Concentration = 0.3mg/kg/hr ÷ 0.5mL/kg/hr = 0.6mg/mL 1
Practical Application
- For a 70kg adult patient receiving 0.3mg/kg/hr:
Important Considerations
- For vasoactive medications (like epinephrine, dopamine), use the most proximal IV site possible to minimize risk of extravasation 1
- Monitor for signs of extravasation, especially with vasoactive medications 1
- For pediatric patients, smaller volumes may be appropriate while maintaining the same concentration 1
- If using an infusion pump, ensure the pump is properly programmed for the concentration and dose 1
Common Pitfalls to Avoid
- Avoid excessive dilution which may lead to fluid overload, especially in patients with heart failure or renal disease 1
- Avoid insufficient dilution which may cause vein irritation 1
- Double-check all calculations to prevent medication errors 1
- Clearly label the infusion with medication name, concentration, and rate 1