Trade Names for Injectable Diphenhydramine in India
Based on the available evidence, there is no specific trade name information for injectable diphenhydramine in India provided in the medical literature reviewed. The guidelines and research evidence do not contain information about brand names of injectable diphenhydramine specifically available in the Indian market.
General Information About Injectable Diphenhydramine
- Injectable diphenhydramine is a histamine H1-receptor antagonist with anticholinergic and sedative properties used in the treatment of allergic symptoms and as an adjunct for sedation in various procedures 1
- The usual dose of intravenous diphenhydramine as an adjunct for endoscopic sedation is 25-50 mg 1
- Diphenhydramine is quickly distributed throughout the body, including the central nervous system, with an onset of action of several minutes and duration of effect up to 4-6 hours 1
Clinical Applications of Injectable Diphenhydramine
- Used in the management of allergic reactions and anaphylaxis 1
- Used as an adjunct to meperidine and midazolam during colonoscopy, showing better overall sedation scores and requiring less meperidine and midazolam 1
- Has a modest stimulatory effect on ventilation and has been reported to counteract opioid-induced hypoventilation 1
- Recommended dose in anaphylaxis management is 1-2 mg/kg or 25-50 mg parenterally 1
Adverse Effects
- Adverse effects include hypotension, dizziness, blurred vision, dry mouth, epigastric discomfort, urinary retention, and wheezing 1
- First-generation antihistamines like diphenhydramine can cause significant sedation and impairment in school and driving performance 1
- Can have anticholinergic effects including dryness of mouth and eyes, constipation, and inhibition of micturition 1
- Increased sensitivity and risk of side effects in older adults with pre-existing comorbid conditions 1
Important Considerations
- Newer second-generation antihistamines have similar efficacy with fewer adverse effects compared to diphenhydramine 2, 3
- Some countries have restricted access to first-generation antihistamines like diphenhydramine due to their adverse effect profile 3
- Diphenhydramine's hypnotic effect is increased when given in combination with alcohol or other central nervous system depressants such as benzodiazepines or opioid narcotics 1
Caution
- Diphenhydramine can be toxic in overdose, with potential for cardiac toxicity 2
- In anaphylaxis management, antihistamines like diphenhydramine are considered second-line therapy to epinephrine and should never be used alone 1
- Careful monitoring is required when administering injectable diphenhydramine, particularly in patients with comorbid conditions 1