Does starting the mini pill (progestin-only pill) more than 24 hours after unprotected sex prevent pregnancy?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: October 15, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

Starting the Mini Pill After Unprotected Sex Does Not Prevent Pregnancy

Starting the progestin-only pill (mini pill) more than 24 hours after unprotected sex will not prevent pregnancy and emergency contraception should be considered instead.

Understanding the Mini Pill and Emergency Contraception

The mini pill (progestin-only pill) is designed for ongoing contraception, not for emergency use after unprotected intercourse. Here's why it doesn't work as emergency contraception:

  • The mini pill requires at least 48 hours of consistent use to achieve contraceptive effects, primarily through thickening cervical mucus 1
  • It takes approximately 7 consecutive days of hormonal contraceptive use to reliably prevent ovulation 2
  • When starting any hormonal contraceptive method, backup contraception or abstinence is needed for the first 2-7 days (depending on the method) 1

What to Do After Unprotected Sex

If more than 24 hours have passed since unprotected intercourse:

  1. Use emergency contraception immediately:

    • Emergency contraceptive pills (ECPs) should be taken as soon as possible within 5 days of unprotected intercourse 1
    • Options include:
      • Ulipristal acetate (30 mg single dose) - most effective option, especially after 72 hours 1, 3
      • Levonorgestrel (1.5 mg single dose) - available over-the-counter 1, 3
      • Copper IUD insertion - most effective overall method, can be inserted up to 5 days after unprotected sex 1, 4
  2. Then start regular contraception:

    • The mini pill can be started immediately after using emergency contraception 2
    • Use backup contraception (condoms) or avoid intercourse for 2 days after starting the mini pill 1

Effectiveness Considerations

  • Emergency contraception effectiveness decreases with time - the sooner it's taken, the more effective it is 3
  • Copper IUDs are the most effective emergency contraception method (>99% effective) 4
  • Ulipristal acetate is more effective than levonorgestrel, especially 3-5 days after unprotected sex 1
  • Levonorgestrel ECPs reduce pregnancy risk by approximately 75% 5
  • Mini pills started after unprotected sex will not prevent pregnancy from that specific encounter 1

Common Pitfalls to Avoid

  • Don't confuse regular contraception with emergency contraception - they serve different purposes and have different timing requirements 1, 2
  • Don't delay seeking emergency contraception - effectiveness decreases with time 3
  • Don't skip using backup contraception when starting hormonal methods like the mini pill 1
  • Don't assume the mini pill provides immediate protection - it takes time to establish contraceptive effect 1
  • Don't forget that emergency contraception is not as effective as regular contraception - establish a reliable ongoing method 6

Remember that emergency contraception should not be considered an alternative to consistent contraceptive use but can prevent unwanted pregnancy when used promptly after unprotected intercourse 5, 7.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Guideline

Starting Combined Oral Contraceptives After Emergency Contraception

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Research

Emergency contraception: a review.

Minerva ginecologica, 2014

Research

Interventions for emergency contraception.

The Cochrane database of systematic reviews, 2008

Research

Emergency contraception.

Archives of family medicine, 2000

Research

Emergency contraception and impact on abortion rates.

Best practice & research. Clinical obstetrics & gynaecology, 2020

Research

An update on emergency contraception.

American family physician, 2014

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.