From the Research
Tums (calcium carbonate) can raise serum calcium levels, but the effect varies based on dosage and individual factors, with a notable increase in serum calcium levels observed in patients taking high doses, such as approximately 1,800 mg of elemental calcium daily, as reported in a case study 1.
Key Considerations
- A standard Tums tablet contains 500-750 mg of calcium carbonate, providing 200-300 mg of elemental calcium.
- For patients taking Tums specifically to increase calcium levels, typical supplementation doses range from 1,000-2,000 mg of elemental calcium daily, divided into multiple doses for better absorption.
- The calcium in Tums is absorbed in the small intestine, requiring stomach acid for optimal absorption, which is why it's best taken with meals.
- Absorption efficiency decreases as dose increases, so splitting doses throughout the day improves overall calcium uptake.
Patient-Specific Factors
- Patients with normal kidney function can typically process this additional calcium, but those with kidney disease, hyperparathyroidism, or who take certain medications like thiazide diuretics should use calcium supplements cautiously as they may experience more significant increases in serum calcium levels and potential complications, as highlighted in a review of hypercalcemia causes and management 2.
- The risk of hypercalcemia is also increased in patients taking certain medications, such as SGLT2 inhibitors, which can lead to dehydration and increased intestinal calcium absorption, as reported in a case study 3.
Recent Findings
- A recent study on the dose-specific effects of denosumab on serum calcium levels in patients with osteoporosis and various renal functions found that the initial dose of denosumab reduced serum calcium levels by an average of 0.34,0.52, and 1.12 mg/dl, in patients with GFR of ≥60,30-59, and < 30 ml/min/1.73m2, respectively 4.
- This study suggests that the effect of calcium supplements on serum calcium levels can vary depending on renal function and other individual factors, emphasizing the need for cautious use and monitoring in patients with kidney disease or other risk factors for hypercalcemia.