Safety of CT Scans While Taking Zepbound (Tirzepatide)
Yes, it is safe to undergo a computed tomography (CT) scan while taking Zepbound (tirzepatide). There are no contraindications or specific precautions needed for patients on tirzepatide who require CT imaging.
Understanding CT Scans and Medication Interactions
- CT scans use X-rays to create detailed images of the body's internal structures and generally do not interact with medications like tirzepatide 1
- Unlike some medications that may require special considerations before imaging procedures, tirzepatide does not have any known interactions with radiological contrast agents or imaging procedures 2, 3
Important Considerations for CT Scans with Contrast
If your CT scan requires intravenous contrast:
Renal function should be checked prior to contrast administration in patients with risk factors including:
- Age over 60 years
- History of kidney disease or impairment
- Diabetes mellitus
- Hypertension requiring medical therapy
- Use of metformin 1
For patients with diabetes on metformin (not specifically tirzepatide):
- Metformin should be discontinued at the time of the procedure and withheld for 48 hours after if IV contrast is administered
- This precaution is related to metformin specifically, not to tirzepatide 1
Tirzepatide-Specific Information
- The safety profile of tirzepatide has been well-documented in clinical trials, with no reported interactions or contraindications related to imaging procedures 3, 4
- Common side effects of tirzepatide are primarily gastrointestinal (nausea, diarrhea, vomiting) and do not impact the safety of undergoing CT scans 4
- There are no recommendations in the medical literature to discontinue tirzepatide before CT scans 2, 3
Patient Preparation for CT Scans
For optimal CT scan results (regardless of tirzepatide use):
- Follow standard preparation instructions provided by your imaging facility
- Maintain proper hydration before the scan (typically 1L of water during the 2 hours prior to the procedure) unless instructed otherwise 1
- Inform your healthcare provider about all medications you're taking, including tirzepatide 1
- If you have diabetes, your healthcare provider may provide specific instructions regarding medication timing and food intake before the scan 1
Conclusion
CT scans are safe for patients taking tirzepatide. The medication does not require any special considerations or discontinuation prior to imaging. Standard protocols for CT scans should be followed, with particular attention to contrast administration guidelines if applicable.