Can Abilify (aripiprazole) cause hair loss?

Aripiprazole and Hair Loss

Yes, Abilify (aripiprazole) can cause hair loss as a documented side effect, though it occurs infrequently. According to the FDA drug label, alopecia is specifically listed as an infrequent adverse reaction in the skin and subcutaneous tissue disorders category 1.

Evidence for Aripiprazole-Induced Hair Loss

• The FDA drug label for aripiprazole explicitly lists alopecia as an "infrequent" adverse reaction under skin and subcutaneous tissue disorders 1
• Medication-induced hair loss is a recognized side effect of various psychopharmaceuticals, including some antipsychotics 2
• Hair loss with antipsychotic medications typically presents as telogen effluvium, where hair follicles prematurely enter the resting phase 3

Frequency and Presentation

• Aripiprazole-induced hair loss is classified as "infrequent" rather than "frequent" in the FDA labeling, suggesting it's not among the most common side effects 1
• When medication-induced hair loss occurs, it typically develops weeks to months after starting treatment 3
• The pattern is usually diffuse thinning rather than patchy hair loss 3

Management Options

• If hair loss is concerning or significant, discuss with your healthcare provider about:
  • Potential dose reduction if clinically appropriate 2
  • Consideration of alternative antipsychotic medications with different side effect profiles 4
  • Evaluation for other causes of hair loss (thyroid dysfunction, nutritional deficiencies) 2
• Medication-induced hair loss is typically reversible upon discontinuation or dose reduction of the causative agent 2

Important Considerations

• The decision to modify treatment should balance the benefits of aripiprazole against the severity of hair loss 4
• Abrupt discontinuation of antipsychotic medication without medical supervision can lead to withdrawal symptoms or relapse of psychiatric symptoms 4
• Other medications commonly associated with higher rates of hair loss include mood stabilizers like lithium (12-19% of long-term users) and valproic acid (up to 12% of patients) 2

When to Seek Medical Attention

• If experiencing noticeable hair loss while taking aripiprazole 3
• If hair loss is accompanied by other concerning symptoms 3
• If hair loss is causing significant psychological distress 3

Remember that while hair loss is a documented side effect of aripiprazole, it occurs infrequently compared to other adverse effects. Always consult with your healthcare provider before making any changes to your medication regimen.