Is rifampin associated with chest pain?

From the FDA Drug Label

Patients should be instructed to notify their physician immediately if they experience any of the following: ... chest pain, Signs and symptoms of hypersensitivity reactions may include ... shortness of breath, chest pain, Other reactions which have occurred with intermittent dosage regimens include ... shortness of breath, wheezing, ... shock, ... The "flu syndrome" may also appear ... shortness of breath, wheezing, ... Pulmonary toxicity (including, but not limited to, ... pneumonitis, hypersensitivity pneumonitis, ... pulmonary infiltrates, ... respiratory failure, ... acute respiratory distress syndrome) has been observed

Chest pain is a reported adverse reaction associated with rifampin 1, 1.

• Hypersensitivity reactions may include chest pain.
• Pulmonary toxicity has been observed, which may manifest as chest pain.
• Patients should be instructed to notify their physician immediately if they experience chest pain.

From the Research

Adverse Effects of Rifampin

• Rifampin has been associated with various adverse effects, including hepatic toxicity and immunoallergic reactions 2
• These immunoallergic effects can be minor, such as a flu-like syndrome, or major, including hemolytic anemia, shock, or acute renal failure 2
• Hypersensitivity reactions to rifampin can also occur, including anaphylactic reactions, which can be life-threatening 3

Specific Adverse Effects

• The studies provided do not specifically mention chest pain as an adverse effect of rifampin 2, 3, 4, 5, 6
• However, rifampin has been associated with a range of other adverse effects, including:
  • Hepatic toxicity 2
  • Immunoallergic reactions 2, 3
  • Hypersensitivity reactions, including anaphylactic reactions 3
  • Pneumonitis 5

Safety of Rifampin

• Rifampin is generally considered to be a safe and effective treatment for latent tuberculosis infection, with a lower risk of adverse events compared to isoniazid 4
• However, rare but serious adverse events can occur, and patients should be carefully monitored for any signs of adverse reactions 4