From the Guidelines
Augmentin XR 1000mg should be dosed as one tablet twice daily (every 12 hours) for adults and adolescents 16 years and older. This dosing recommendation is based on the most recent and highest quality study available, which provides guidance on the diagnosis and treatment of adults with community-acquired pneumonia 1.
Key Considerations
- The standard duration of treatment is 7-10 days depending on the infection being treated.
- Each tablet contains 875mg of amoxicillin and 125mg of clavulanic acid in an extended-release formulation.
- Augmentin XR should be taken with food at the start of a meal to enhance absorption and reduce gastrointestinal side effects.
Important Details
- The extended-release formulation maintains therapeutic blood levels longer than standard Augmentin, allowing for twice-daily dosing while providing better coverage against resistant bacteria.
- It's essential to complete the full prescribed course even if symptoms improve before finishing.
- Common side effects include diarrhea, nausea, and rash.
- Patients with kidney impairment may require dose adjustment, and those with a history of penicillin allergy should not take this medication.
- Augmentin XR is not recommended for children under 16 years of age due to limited safety and efficacy data in this population.
Clinical Context
- The dosing of Augmentin XR 1000mg is crucial in the treatment of community-acquired pneumonia, as well as other infections, and should be guided by the most recent and highest quality evidence available 1.
From the Research
Dosing Information for Augmentin (amoxicillin/clavulanate) XR 1000mg
- The dosing for Augmentin (amoxicillin/clavulanate) XR is 2000mg/125mg twice daily, as stated in the studies 2, 3, 4, 5.
- However, the question asks for the dosing of Augmentin (amoxicillin/clavulanate) XR 1000mg, which is not explicitly mentioned in the provided studies.
- According to the study 5, the formulation of amoxicillin-clavulanate potassium extended-release tablets is 2 x 1,000 mg/62.5 mg every 12 hours, which can be inferred as the dosing for Augmentin (amoxicillin/clavulanate) XR 1000mg.
- It is essential to note that the provided studies primarily discuss the 2000mg/125mg formulation, and the information on the 1000mg formulation is limited.
Key Points to Consider
- The studies 2, 3, 4, 5 focus on the efficacy and safety of Augmentin (amoxicillin/clavulanate) XR in treating community-acquired respiratory tract infections.
- The dosing regimen of 2000mg/125mg twice daily is consistently mentioned across the studies.
- The study 6 compares the efficacy and safety of oral pharmacokinetically enhanced amoxycillin-clavulanate 2000/125 mg, twice daily, versus oral amoxycillin-clavulanate 1000/125 mg, three times daily, but does not provide information on the XR formulation.