What is the recommended dose of Aminoven (parenteral nutrition solution)?

Recommended Dosage of Aminoven (Parenteral Nutrition Solution)

The recommended dose of Aminoven (parenteral amino acid solution) varies by age group, with adults requiring 1.3-1.5 g/kg/day in stable conditions and up to 2.0-2.5 g/kg/day in specific critical conditions. 1

Adult Dosing Guidelines

• For stable adult patients with normal metabolism, an amino acid intake of 0.8 g/kg/day is generally recommended, which may be increased to 1.2-1.5 g/kg/day 2
• For critically ill adult patients, the optimal protein-sparing effects are achieved with amino acid infusion rates of 1.3-1.5 g/kg/day 1
• In exceptional cases such as severe trauma or sepsis, doses may be increased to 2.0-2.5 g/kg/day 2, 3
• For peripheral intravenous infusion, 1-1.5 g/kg/day of total amino acids will reduce protein catabolism 4

Pediatric Dosing Guidelines

• For infants and children from 1 month to 3 years: A minimum amino acid intake of 1.0 g/kg/day should be administered in stable conditions 1
• For children aged 3-12 years: An amino acid intake of 1.0-2.0 g/kg/day is recommended in stable conditions 1
• For adolescents: An amino acid intake of at least 1.0 with a maximum of 2.0 g/kg/day is recommended in stable conditions 1
• For preterm infants: 2.5-3.5 g/kg/day of parenteral amino acids from postnatal day 2 onwards 5

Administration Considerations

• Sufficient non-nitrogen energy sources should be added to ensure adequate utilization of amino acids 2
• A nitrogen-calorie ratio of 1:130 to 1:170 (g N/kcal) or 1:21 to 1:27 (g AA/kcal) is recommended under normal metabolic conditions 2
• For peripheral vein administration, amino acid solutions should be diluted to a final concentration of 5% to 10% 4
• For central vein infusion, solutions containing 3.5-5% amino acids with 5-10% glucose may be infused 4

Special Considerations

• In critically ill patients, glutamine should be administered parenterally if indicated at 0.2-0.4 g/kg/day 1
• In patients with acute renal failure receiving continuous renal-replacement therapy, higher amino acid intakes (up to 0.4 g nitrogen/kg/day) may be required 1
• In hypercatabolic patients receiving hypocaloric feeding, nitrogen requirements may be increased by 25-30% 1

Common Pitfalls to Avoid

• Avoid exceeding recommended doses without monitoring, as high doses of amino acids may lead to side effects including renal dysfunction, gastrointestinal disturbances, and ammonia production 6
• Avoid inadequate non-protein caloric intake, which can impair amino acid utilization 5, 2
• Avoid delaying amino acid administration in critical conditions, which can result in protein catabolism and negative nitrogen balance 5
• Monitor serum electrolytes regularly, as electrolyte abnormalities can occur with parenteral amino acid administration 7, 4

Monitoring Recommendations

• Regular monitoring of nitrogen balance and accurate daily body weights (corrected for fluid balance) are recommended to assess individual protein requirements 4
• Serum electrolytes should be monitored as indicated, particularly sodium, chloride, potassium, phosphate, calcium, and magnesium 4
• In patients receiving long-term parenteral nutrition, monitor for potential side effects of prolonged high-dose amino acid supplementation 6, 8