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Last updated: October 16, 2025View editorial policy

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Differential Diagnosis for Patient with Side Pain and Possible Kidney Infection

Single Most Likely Diagnosis

  • Pyelonephritis: This is the most likely diagnosis given the patient's complaint of side pain, possible kidney infection, and lower back pain. Pyelonephritis is an infection of the kidney, which can cause flank pain, lower back pain, and other symptoms such as fever and dysuria.

Other Likely Diagnoses

  • Nephrolithiasis (Kidney Stones): Kidney stones can cause severe flank pain and lower back pain, which can radiate to the groin area. The pain can be intermittent or constant and is often accompanied by nausea, vomiting, and dysuria.
  • Musculoskeletal Strain: Given the patient's complaint of lower back pain, a musculoskeletal strain should be considered, especially if the patient has recently engaged in heavy lifting or strenuous activity.
  • Urinary Tract Infection (UTI): While the patient mentions a possible kidney infection, a lower urinary tract infection (such as cystitis) could also cause similar symptoms, including dysuria, frequency, and lower abdominal pain.

Do Not Miss Diagnoses

  • Appendicitis: Although appendicitis typically presents with right lower quadrant pain, it can occasionally present with flank or lower back pain if the appendix is retrocecal. Missing this diagnosis could lead to severe consequences, including perforation and peritonitis.
  • Pulmonary Embolism: In rare cases, a pulmonary embolism can cause flank or back pain if the embolism is large and affects the pulmonary vessels near the spine. This diagnosis is critical to consider due to its high mortality rate if untreated.
  • Aortic Dissection: An aortic dissection can cause severe back pain that radiates to the flank area. This is a medical emergency that requires immediate attention to prevent fatal outcomes.

Rare Diagnoses

  • Pneumonia: Certain types of pneumonia, especially those affecting the lower lobes, can cause referred pain to the back or flank area.
  • Pancreatitis: Pancreatitis can cause severe back pain, especially if the pancreas is inflamed and irritating the surrounding tissues and nerves.
  • Spinal Infection or Abscess: Infections of the spine, such as osteomyelitis or epidural abscess, can cause back pain and are medical emergencies due to the risk of neurological compromise and sepsis.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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