Recommended Dosage of Mucinex (Guaifenesin) for Adults
The recommended dose of Mucinex (guaifenesin) for adults is 10 to 20 mL (2 to 4 teaspoons) every 4 hours, not exceeding 6 doses in any 24-hour period. 1
Immediate-Release vs Extended-Release Formulations
Immediate-Release Formulation
- Standard dosing is 200-400 mg every 4 hours, up to 6 times daily 2
- This frequent dosing schedule is necessary due to guaifenesin's short half-life 3
- Maximum daily dose should not exceed 2400 mg 1
Extended-Release Formulation
- Extended-release tablets (Mucinex) are dosed at 600-1200 mg every 12 hours 3
- This provides a convenient alternative to the 4-hour dosing schedule of immediate-release formulations 3
- Extended-release formulation has been shown to be bioequivalent to corresponding doses of immediate-release guaifenesin 3
Safety Profile
- Guaifenesin has a well-established and favorable safety and tolerability profile in adult populations 2
- Most common adverse effects are mild and include gastrointestinal symptoms, nervous system effects, and skin reactions 4
- All reported adverse events in clinical studies were mild in severity with no serious adverse events reported 4
Clinical Considerations
- Guaifenesin acts as an expectorant by loosening mucus in the airways and making coughs more productive 2
- It is primarily used for relief of wet cough and chest congestion due to common cold 2
- While generally safe, caution should be exercised with extremely high doses as there has been a case report of central nervous system depression following overdose 5
Administration Tips
- Extended-release tablets should be taken whole and not crushed or chewed 3
- Food may affect the absorption rate (Tmax) but not the overall bioavailability of extended-release guaifenesin 3
- For optimal effect, maintain adequate hydration while taking guaifenesin 2
Remember that guaifenesin is available in multiple formulations and strengths, so always check the specific product labeling for the exact dosing instructions for that particular formulation 1, 2.