From the Research
I do not recommend Requip (ropinirole) for generalized restlessness caused by Vraylar (cariprazine). The restlessness you're experiencing is likely akathisia, a common side effect of antipsychotic medications like Vraylar, as reported in a study published in 2021 1. Adding Requip, a dopamine agonist, could potentially worsen your psychiatric symptoms since it works opposite to Vraylar's dopamine-blocking mechanism.
Alternative Treatment Options
Instead, speak with your prescriber about several better options:
- Reducing your Vraylar dose
- Switching to a different antipsychotic with lower akathisia risk
- Adding medications specifically for akathisia such as propranolol (20-40mg three times daily), benzodiazepines like lorazepam (0.5-1mg as needed), or anticholinergics like benztropine (1-2mg daily), as suggested by a study published in 2021 2
- Non-medication approaches like regular exercise and stress reduction techniques may also help
Importance of Prompt Treatment
This restlessness should be addressed promptly as it can significantly impact your quality of life and medication adherence, as highlighted in a study published in 2018 3. Always consult your healthcare provider before making any medication changes. The current evidence best supports the use of propranolol and mirtazapine for the management of akathisia, as reported in a study published in 2021 2.