Domperidone Dosing for an 11kg Pediatric Patient
For an 11kg pediatric patient, the recommended dose of domperidone is 0.3 mg/kg three times daily before meals, which equals 3.3 mg per dose (total daily dose of 9.9 mg). 1
Dosing Calculation and Administration
- The standard pediatric dosing for domperidone is 0.3 mg/kg given three times daily (t.d.s.) before meals 1
- For an 11kg child: 0.3 mg/kg × 11kg = 3.3 mg per dose
- Total daily dose: 3.3 mg × 3 = 9.9 mg per day
- Domperidone is available in liquid formulation (drops), which facilitates administration to young children 1
Clinical Considerations
- Domperidone has been shown to be effective for treating chronic vomiting and regurgitation in infants and children 1
- Studies have demonstrated that domperidone is significantly more effective than placebo and may be superior to metoclopramide for controlling vomiting symptoms in pediatric patients 1
- Domperidone has a better safety profile compared to other antiemetics like metoclopramide, with fewer central nervous system side effects 1, 2
Safety Warnings and Precautions
- Maximum daily dosage should not exceed 30 mg due to risk of QT prolongation and potential cardiac adverse effects 3, 4
- Duration of treatment should be limited to 7 days when possible 3
- Avoid co-administration with medications that can prolong the QT interval 3, 4
- In 2014, safety warnings were issued regarding cardiac effects of domperidone in children, leading to more cautious prescribing patterns 3
Monitoring Requirements
- Monitor for potential side effects, including cardiac symptoms
- Pain at the site of intravenous administration has been reported if domperidone is not adequately diluted (relevant only for IV administration) 5
- For chronic conditions requiring longer treatment, regular reassessment of the need for continued therapy is recommended 3
Alternative Considerations
- For acute gastroenteritis-associated vomiting, ondansetron (0.15 mg/kg) may be more efficacious than domperidone (0.5 mg/kg) at 24 hours post-treatment 2
- Consider the specific indication for antiemetic therapy when selecting between domperidone and other agents 2
Remember that domperidone should be used at the lowest effective dose for the shortest duration necessary to control symptoms while minimizing potential adverse effects.