Cefpodoxime Dosage for a 45-Month-Old Child
The recommended dosage of cefpodoxime proxetil syrup for a 45-month-old child is 8-10 mg/kg/day divided into two doses (given every 12 hours). 1, 2
Dosing Considerations
- Cefpodoxime proxetil is a semi-synthetic, third-generation cephalosporin available as an oral prodrug that is readily absorbed from the gut 1
- For common pediatric infections, the standard dosage range is 8-10 mg/kg/day divided into two doses 2
- For a 45-month-old child (approximately 3.75 years), the twice-daily dosing schedule is appropriate and helps with medication adherence 1
- Treatment duration typically ranges from 5-10 days depending on the type and severity of infection 2
Clinical Applications
- Cefpodoxime is effective for common pediatric infections including:
Pharmacokinetic Considerations
- The drug reaches adequate levels exceeding the minimum inhibitory concentration (MIC) in most body fluids 1
- Cefpodoxime is primarily excreted unchanged by the kidneys 1
- The twice-daily dosing is supported by the pharmacokinetic profile of the medication 2
Antimicrobial Spectrum
- Cefpodoxime is active against common pathogens including:
Special Considerations
- For severe infections requiring initial parenteral therapy, cefpodoxime can be used as step-down therapy after improvement with IV antibiotics 1
- The medication is generally well-tolerated with primarily gastrointestinal disturbances and skin rashes as potential adverse effects 2
- Dose adjustment may be necessary in children with compromised renal function 1
Clinical Efficacy
- Clinical studies have demonstrated that cefpodoxime proxetil is at least as effective as standard regimens of amoxicillin/clavulanic acid, cefixime, cefuroxime axetil, or cefaclor in pediatric infections 2
- The favorable twice-daily dosing schedule can improve medication adherence compared to medications requiring more frequent administration 2