Ertapenem Reconstitution with Lidocaine 3.2ml
When reconstituting Ertapenem with 3.2ml of Lidocaine, the total volume is 4.2ml. 1
Reconstitution Process Details
- Ertapenem 1g powder contributes approximately 1ml to the final volume when reconstituted 1
- Adding 3.2ml of lidocaine diluent to the powder results in a total solution volume of 4.2ml 1
- The reconstitution with lidocaine is specifically used for intramuscular (IM) administration 2
Clinical Applications for IM Administration
- IM ertapenem is particularly valuable when vascular access is limited or unavailable in emergency situations 3
- The standard dose for IM administration is 1g once daily 2
- When reconstituted with lidocaine, IM ertapenem has been shown to be generally well tolerated with a safety profile comparable to IM ceftriaxone 2
Important Considerations
- Carbapenems, including ertapenem, are particularly unstable after reconstitution and should not be stored for extended periods 4
- The most common local symptoms after IM administration are tenderness and pain at the injection site 2
- For intramuscular administration, lidocaine is used as the diluent to reduce injection site pain 2
Administration Guidelines
- For intravenous administration, different diluents are used (not lidocaine), and the reconstitution volume would differ 5
- IM administration should be considered only when timely establishment of vascular access is not possible 3
- The bioavailability of IM ertapenem is approximately 92% compared to IV administration 6