Management of Persistent Bump After Sublocade Injection
A persistent bump at the injection site one month after Sublocade (buprenorphine) administration is a normal occurrence and typically requires no intervention as long as there are no signs of infection or severe inflammation. 1
Understanding Sublocade Injection Site Reactions
- Injection site reactions are documented adverse effects of subcutaneous buprenorphine (Sublocade), occurring in less than 1% of patients according to FDA data 1
- The 2-inch bump you're experiencing is likely the medication depot, which is designed to slowly release buprenorphine over time 2
- These bumps can persist for weeks to months as the medication is gradually absorbed 2
Assessment of the Injection Site
Normal Findings (No Action Required):
- Firm, non-tender bump at injection site 1
- No significant redness, warmth, or drainage 1
- No fever or systemic symptoms 1
Concerning Findings (Seek Medical Attention):
- Signs of infection (increasing redness, warmth, tenderness, purulent drainage) 1
- Severe pain at injection site 1
- Systemic symptoms like fever 1
- Signs of allergic reaction (widespread rash, hives, difficulty breathing) 1
Management Recommendations
For Normal Injection Site Bumps:
- Continue your regular Sublocade treatment schedule 2
- Avoid massaging or manipulating the injection site as this could affect medication release 3
- Apply a loose, porous bandage if needed for comfort or to prevent clothing irritation 4
When to Seek Medical Attention:
- If the bump becomes increasingly painful, red, or warm 1
- If you develop fever or other systemic symptoms 1
- If you notice any drainage from the site 1
- If you experience signs of allergic reaction such as widespread rash, hives, or difficulty breathing 1
Important Considerations for Patients on Sublocade
- Sublocade is a long-acting formulation designed to maintain stable buprenorphine levels over time 2
- The medication depot is intentionally designed to dissolve slowly, which explains the persistent bump 3
- Future injections should be administered at different sites to avoid overlapping depots 2
- The persistence of the bump does not indicate reduced effectiveness of the medication 2
Prevention of Future Injection Site Reactions
- Ensure proper injection technique is used by healthcare providers 2
- Rotate injection sites with each administration 2
- Maintain good hygiene around the injection site 4
- Avoid tight clothing or belts that might irritate the injection site 4
Remember that the presence of the bump is generally part of the normal medication delivery system and not cause for concern unless accompanied by signs of infection or severe inflammation 1, 2.