Normal Dosing of Dulcolax (Bisacodyl) Suppository for Adults
The normal dosing of Dulcolax (bisacodyl) suppository for an adult is 1 suppository (10 mg) in a single daily dose. 1
Administration Instructions
- Insert the suppository well into the rectum, pointed end first 1
- Retain for approximately 15-20 minutes for optimal effect 1
- The onset of action for rectal bisacodyl suppositories is typically within 30-60 minutes 2
Mechanism of Action
- Bisacodyl is a stimulant laxative that is converted in the gut into its active metabolite, bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM) 2
- BHPM acts directly on the colonic mucosa to stimulate colonic peristalsis and secretion 2
- The suppository form works more quickly than oral tablets, providing faster relief of constipation 3
Clinical Considerations
- Bisacodyl suppositories are a preferred first-line therapy when digital rectal examination identifies a full rectum or fecal impaction 2
- The suppository form produces a prompt laxative effect (within approximately 20 minutes) compared to oral tablets (which take 6-12 hours) 3
- Suppositories may be more effective than tablets alone for bowel preparation and management of constipation 4
Precautions and Contraindications
- Bisacodyl is contraindicated in individuals with ileus, intestinal obstruction, severe dehydration, or acute inflammatory conditions in the bowel 2
- Use with caution in patients with inflammatory bowel conditions as bisacodyl can cause sloughing of surface epithelium and mucosal changes 5
- Avoid use in children under 6 years of age 1
Side Effects
- Common adverse effects include diarrhea and abdominal pain 2
- Bisacodyl suppositories may cause local rectal irritation 5
- Prolonged or excessive use can lead to electrolyte imbalances and dependence 6
Special Populations
- In palliative care settings, bisacodyl may be used at doses of 10-15 mg daily to three times daily for severe constipation 2
- For elderly patients, standard adult dosing applies, but monitor more closely for side effects 6
Remember that bisacodyl suppositories are generally recommended for short-term use rather than long-term treatment 2. For chronic constipation management, consider alternating with other laxative types or consulting with a specialist for a comprehensive bowel management plan.