From the Guidelines
The recommended dose of Augmentin (amoxicillin-clavulanate) for pediatric patients with streptococcal pharyngitis is not explicitly stated in the provided evidence, but based on the available information, the dose of amoxicillin, a component of Augmentin, is 50 mg/kg once daily (max = 1000 mg) or 25 mg/kg (max = 500 mg) twice daily for 10 days 1.
Key Considerations
- The provided evidence does not directly mention the dose of Augmentin for streptococcal pharyngitis, but it does provide dosing information for amoxicillin, which is a part of the Augmentin combination.
- Amoxicillin is recommended at a dose of 50 mg/kg once daily (max = 1000 mg) or 25 mg/kg (max = 500 mg) twice daily for 10 days 1.
- It's crucial to note that Augmentin is not listed as a first-line treatment in the provided evidence, but rather amoxicillin alone is recommended for the treatment of streptococcal pharyngitis.
- The importance of completing the full 10-day course of antibiotics, even if symptoms improve earlier, cannot be overstated, as it ensures the complete eradication of the bacteria and prevents complications like rheumatic fever.
Treatment Options
- First-line treatment: Amoxicillin at 50 mg/kg/day (maximum 1000 mg daily) given once daily for 10 days 1.
- Alternative treatments are listed for patients with penicillin allergy or other specific conditions, but Augmentin's dose is not explicitly mentioned in the context of streptococcal pharyngitis treatment.
Side Effects and Considerations
- Common side effects of Augmentin include diarrhea, nausea, and rash.
- It's essential to consider the potential for antibiotic resistance and the importance of using antibiotics judiciously to minimize this risk.
From the FDA Drug Label
In Pediatric Patients over 3 Months of Age, 20 to 45 mg/kg/day in divided doses every 8 to 12 hours.
The dose of amoxicillin for pediatric patients with streptococcal pharyngitis is 20 to 45 mg/kg/day.
- The dose is given in divided doses every 8 to 12 hours.
- Note that Augmentin is a combination of amoxicillin and clavulanate, but the provided label is for amoxicillin only 2.
From the Research
Dosage Information for Augmentin in Pediatric Patients with Strep Throat
- The recommended dosage of Augmentin (amoxicillin-clavulanate) for pediatric patients with streptococcal pharyngitis is not explicitly stated in the provided studies as a specific mg/kg dose for this particular condition.
- However, study 3 mentions that amoxicillin was administered at a dose of 40-50 mg/kg/day for the treatment of group A streptococcal pharyngitis.
- Study 4 compares the efficacy and safety of amoxicillin (50 mg/kg/day divided twice daily) for 6 days and penicillin V for 10 days in children with group A streptococcal tonsillopharyngitis, indicating a specific dosage for amoxicillin in this context.
- It's worth noting that the dosage for Augmentin can vary based on the specific formulation and the condition being treated, as seen in studies 5, 6, and 7 which discuss different formulations and dosages for various infections.
Considerations for Treatment
- The choice of antibiotic and dosage should be based on the specific needs of the patient and the severity of the infection.
- Studies 3 and 4 provide evidence for the effectiveness of amoxicillin in treating streptococcal pharyngitis, but the specific dosage of Augmentin (amoxicillin-clavulanate) for this condition is not directly addressed in the provided texts.