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Last updated: October 17, 2025View editorial policy

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Differential Diagnosis for Fluid Filled Bumps on One Side of Labia Majora

Single Most Likely Diagnosis

  • Bartholin's cyst: This is the most likely diagnosis due to the location (one side of the labia majora) and description (fluid-filled bumps) of the symptoms. Bartholin's cysts occur when the Bartholin's gland, located on each side of the vaginal opening, becomes blocked, causing a fluid-filled cyst to form.

Other Likely Diagnoses

  • Folliculitis: An inflammation of the hair follicles, which can cause bumps or pus-filled spots on the skin, including the labia majora.
  • Sebaceous cyst: A benign, fluid-filled cyst that can occur on the labia majora, although less common than Bartholin's cyst in this specific location.
  • Vulvar abscess: A collection of pus in the vulvar area, which can cause a painful, fluid-filled bump.

Do Not Miss Diagnoses

  • Malignancy (e.g., vulvar cancer): Although rare, any unusual or persistent lump in the genital area should be evaluated for the possibility of cancer to ensure early detection and treatment.
  • Herpes simplex virus (HSV) infection: Can cause painful, fluid-filled blisters in the genital area, including the labia majora.
  • Syphilis: A sexually transmitted infection that can cause a variety of symptoms, including painless sores or bumps in the genital area.

Rare Diagnoses

  • Hydrocele of the labia majora: A rare condition where fluid accumulates in the labia majora, similar to a hydrocele in the testicles.
  • Vulvar hidradenoma: A rare, benign tumor of the sweat glands that can occur in the vulvar area, including the labia majora.
  • Lymphangioma: A rare, benign growth of the lymphatic vessels that can cause fluid-filled bumps or lesions in various parts of the body, including the genital area.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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