What is the recommended daily calorie intake for individuals taking Latuda (lurasidone)?

Latuda (Lurasidone) Must Be Taken With At Least 350 Calories of Food

Latuda (lurasidone) must be taken with a meal containing at least 350 calories to ensure proper absorption and effectiveness of the medication. 1, 2

Food Requirements for Latuda Administration

• Latuda should always be taken with food (at least 350 calories) as administration with food substantially increases the absorption of lurasidone 1
• Taking Latuda in a fasted state results in significantly lower drug exposure compared to taking it with food 2
• The FDA drug label specifically states that Latuda should be taken with food to ensure proper absorption 1
• Clinical studies have shown that lurasidone exposure was similar following meals containing 350-1000 calories, regardless of fat content 2

Specific Caloric Requirements

• A minimum of 350 calories is required when taking Latuda to ensure maximum bioavailability 2
• Studies show that lurasidone exposure following smaller meals (100-200 calories) was substantially lower than with meals containing 350+ calories 2
• Without adequate food intake, the maximum serum concentration (Cmax) of lurasidone can be reduced by more than 50% 2
• The area under the curve (AUC) measurement of drug exposure is significantly higher when Latuda is taken with food versus in a fasted state 2

Practical Meal Planning with Latuda

• For patients taking Latuda, a balanced meal following general dietary guidelines would be appropriate 3
• A typical balanced meal should contain:
  • Moderate reduction in total fat (≤30% of total calories) 3
  • Carbohydrates (55-60% of total calories) 3
  • Protein (15-20% of total calories) 3
• Emphasis should be placed on including fiber-rich foods and whole grains while reducing saturated fats 3

General Caloric Recommendations

• For general weight management, nutritionally balanced diets typically provide 1200-1500 kcal/day for women and 1500-1800 kcal/day for men 3
• These caloric targets should be adjusted based on individual factors such as age, sex, weight, height, and activity level 4
• A 500-750 kcal/day energy deficit is the standard recommendation for achieving clinically meaningful weight loss 4

Important Considerations and Pitfalls

• Failure to take Latuda with adequate food (at least 350 calories) will result in significantly reduced drug exposure, potentially compromising its therapeutic effectiveness 2
• The caloric requirement for Latuda is specific and should not be confused with general dietary recommendations for weight management 1, 2
• The food requirement is independent of fat content - both low-fat and high-fat meals are effective as long as they contain at least 350 calories 2
• Patients should be counseled that skipping meals while taking Latuda could lead to treatment failure due to inadequate drug absorption 2

Special Populations

• For patients with moderate to severe renal or hepatic impairment, the dosing recommendations for Latuda may be adjusted, but the requirement to take it with food remains unchanged 1
• Patients taking medications that affect CYP3A4 (inhibitors or inducers) may need dose adjustments of Latuda, but should still maintain the requirement of taking it with at least 350 calories 1