What is the recommended treatment for a tooth infection?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: October 17, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

Treatment for Tooth Infection

The primary treatment for dental infections is surgical intervention, including root canal therapy for salvageable teeth, extraction for non-restorable teeth, and incision and drainage for accessible abscesses, with antibiotics reserved only for cases with systemic involvement or risk of spread. 1

Surgical Management (First-Line Treatment)

  • Surgical intervention is the cornerstone of treatment for dental infections and should be performed before considering antibiotic therapy 1, 2
  • For salvageable teeth, root canal therapy (endodontic treatment) is the preferred option 2
  • For non-restorable teeth, extraction is recommended 1, 3
  • Immediate extraction of teeth in acute infection settings has shown to be beneficial, resulting in faster resolution of infection, decreased pain, and earlier return of function 3
  • Incision and drainage should be performed for accessible abscesses 1

When Antibiotics Are Indicated (Adjunctive Treatment)

Antibiotics should be prescribed only in the following situations:

  • Presence of systemic involvement (fever, malaise, lymphadenopathy) 1, 2
  • Immunocompromised patients 1, 2
  • Infections extending into facial spaces or cervicofacial tissues 1, 2
  • Failure to respond to surgical treatment alone 1
  • Diffuse swelling that cannot be drained effectively 1, 4

Antibiotic Selection

When antibiotics are indicated:

  • Amoxicillin is the first-line antibiotic at a dose of 500 mg three times daily for 5 days 2, 5
  • For more severe infections, amoxicillin-clavulanic acid should be used when there is inadequate response to amoxicillin alone 2, 6
  • For patients with penicillin allergy, clindamycin is the recommended alternative at a dose of 150-300 mg every 6 hours for serious infections 2, 7, 4
  • Treatment should continue for a minimum of 48 to 72 hours beyond the time that the patient becomes asymptomatic 5

Important Considerations

  • Proper infection control practices must be followed during dental procedures to prevent cross-contamination 8, 1
  • Antibiotics should not be used as a substitute for appropriate surgical intervention, as they do not eliminate the source of infection 1, 4
  • For infections caused by Streptococcus pyogenes, treatment should continue for at least 10 days to prevent acute rheumatic fever 5
  • In patients with renal impairment (GFR <30 mL/min), dosage adjustments for amoxicillin are necessary 5

Common Pitfalls to Avoid

  • Prescribing antibiotics without surgical intervention is ineffective and contributes to antibiotic resistance 1, 4
  • Using antibiotics as the sole treatment modality without addressing the underlying dental issue 2, 9
  • Overuse of broad-spectrum antibiotics in cases where they are not indicated (such as symptomatic irreversible pulpitis, necrotic pulps, and localized acute apical abscesses) 4

References

Guideline

Treatment for Tooth Infection in Adults

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Guideline

Dental Infection Treatment Guidelines

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Research

Should teeth be extracted immediately in the presence of acute infection?

Oral and maxillofacial surgery clinics of North America, 2011

Research

Antibiotics in Endodontics: a review.

International endodontic journal, 2017

Research

[Judicious use of antibiotics in dental practice].

Refu'at ha-peh veha-shinayim (1993), 2004

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Antibiotic use in dental practice. A review.

Medicina oral, patologia oral y cirugia bucal, 2007

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.