What is the safety and efficacy of ultrasound therapy to treat cellulite (subcutaneous fat)?

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Last updated: March 24, 2025View editorial policy

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From the Guidelines

Ultrasound therapy for cellulite is not supported by the provided evidence, and its safety and efficacy are unclear in this context. The available studies do not directly address the use of ultrasound therapy for treating cellulite, and therefore, it is difficult to make a definitive recommendation.

  • The study published in Theranostics 1 focuses on ultrasound-mediated drug delivery to the eye, which is not relevant to the treatment of cellulite.
  • The study published in The Journal of Urology 1 discusses various emerging therapies for benign prostatic hyperplasia, including high-intensity focused ultrasound, but does not provide information on the use of ultrasound therapy for cellulite. Given the lack of direct evidence, it is recommended to exercise caution and consider alternative treatments for cellulite that have a more established safety and efficacy profile.
  • Patients with cellulite should consult with a qualified healthcare professional to discuss the best course of treatment, which may include a combination of lifestyle modifications, such as regular exercise, proper hydration, and a balanced diet, as well as other evidence-based therapies.
  • It is essential to prioritize the patient's safety and well-being, and to avoid using unproven or experimental treatments that may pose unnecessary risks.

From the Research

Safety and Efficacy of Ultrasound Therapy for Cellulite Treatment

  • The safety and efficacy of ultrasound therapy for treating cellulite have been explored in various studies, with some indicating potential benefits 2, 3, 4.
  • A study published in 2019 found that acoustic wave therapy, subcision, and the 1440-nm Nd:YAG minimally invasive laser demonstrated the most beneficial results in cellulite reduction, although the evidence for ultrasound therapy specifically was not extensively discussed 2.
  • Another study from 2015 noted that while there is some evidence for the potential benefit of acoustic wave therapy, the overall quality of evidence for cellulite treatments, including ultrasound, is limited due to methodological flaws in many studies 3.
  • A 2024 review suggested that non-invasive treatment options, including ultrasound, may be effective for moderate cellulite, although radiofrequency demonstrated the strongest efficacy in the current literature 4.

Ultrasound Therapy in Cellulite Reduction

  • There is limited direct evidence on the use of ultrasound therapy for cellulite reduction, with most studies focusing on other treatments like radiofrequency, laser therapy, and mesotherapy 5, 6.
  • A study on intradermal mesotherapy used high-frequency ultrasound for monitoring and found significant reductions in cellulite severity, but this does not directly relate to the use of ultrasound as a therapeutic modality for cellulite treatment 6.
  • The efficacy and safety of ultrasound therapy specifically for cellulite treatment would require more targeted research to fully understand its potential benefits and limitations 4.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Treatment for cellulite.

International journal of women's dermatology, 2019

Research

Cellulite: an evidence-based review.

American journal of clinical dermatology, 2015

Research

Treatment of abdominal cellulite and circumference reduction with radiofrequency and dynamic muscle activation.

Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology, 2015

Research

Efficacy of intradermal mesotherapy in cellulite reduction - Conventional and high-frequency ultrasound monitoring results.

Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology, 2017

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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