Rheumatoid Arthritis (RA): Given the swelling and tenderness in the knee joint, along with symptoms like itching in the eye and hands, which could be indicative of associated conditions such as dry eye syndrome or palmar erythema, RA is a strong consideration. The sudden onset of symptoms and the patient's age also support this diagnosis. However, the presence of diabetes and hypertension, while common in this age group, doesn't directly point to RA but doesn't rule it out either.

Gout: The acute onset of joint pain and swelling, particularly in the context of dietary triggers (e.g., hot and spicy food), could suggest gout. The patient's history of hypertension is also relevant, as diuretics used to treat hypertension can increase uric acid levels, predisposing to gout.
Osteoarthritis (OA): While OA is common in this age group, the sudden onset of symptoms and the specific combination of symptoms (e.g., itching in the eye and hands) are less typical for OA. However, OA cannot be ruled out without further evaluation.
Diabetic Neuropathy: The patient's history of diabetes, combined with symptoms like itching in the hands and potentially altered wound healing, could suggest diabetic neuropathy. However, this doesn't directly explain the knee joint symptoms.

Septic Arthritis: Although less likely given the description, septic arthritis is a medical emergency that requires prompt diagnosis and treatment. The presence of sudden, severe joint pain and swelling, especially in the context of diabetes (which can impair immune response), makes this a critical diagnosis not to miss.
Cellulitis or Skin Infection: Given the patient's diabetes and potential for impaired wound healing, cellulitis or another skin infection could be present, especially if there's an open wound or recent trauma to the area.
Lymphoma or Other Malignancies: Certain malignancies can cause a variety of systemic symptoms, including joint pain, itching (pruritus), and impaired wound healing. While less common, these diagnoses are critical not to miss due to their significant implications for treatment and prognosis.

Sarcoidosis: This condition can cause a wide range of symptoms, including joint pain, eye symptoms (like uveitis), and skin manifestations. While rare, sarcoidosis could potentially explain the combination of symptoms if other diagnoses are ruled out.
Amyloidosis: A group of diseases characterized by the deposition of amyloid proteins in various tissues, amyloidosis can cause a variety of symptoms, including joint pain, neuropathy, and potentially impaired wound healing. It's a rare condition but could be considered if more common diagnoses are excluded.