Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: October 18, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

Differential Diagnosis for Protein Elevation in Cat with High CSF RBC or Hemorrhagic Tap

Single Most Likely Diagnosis

  • Traumatic Tap: This is the most likely diagnosis due to the presence of high CSF RBC, which suggests that the blood in the cerebrospinal fluid (CSF) is a result of the tap procedure itself, potentially causing a temporary elevation in protein levels due to the introduction of blood into the CSF.

Other Likely Diagnoses

  • Vascular Malformation or Hemorrhage: Conditions such as arteriovenous malformations or other vascular anomalies could lead to bleeding into the CSF, resulting in both elevated RBCs and protein.
  • Inflammatory or Infectious Conditions: Certain infections or inflammatory processes within the central nervous system (CNS) could cause an increase in CSF protein and, in some cases, lead to hemorrhage, although the latter is less common.
  • Neoplasia: Tumors within the CNS could potentially cause both an elevation in CSF protein due to disruption of the blood-brain barrier and hemorrhage, either due to tumor necrosis or invasion into blood vessels.

Do Not Miss Diagnoses

  • Bacterial Meningitis: Although less likely to present with hemorrhage, bacterial meningitis is a critical diagnosis that must be considered due to its high morbidity and mortality if not promptly treated. The presence of blood could be due to severe inflammation causing vascular damage.
  • Fungal or Protozoal Infections: Similar to bacterial meningitis, these infections are less common but can have severe outcomes if not diagnosed and treated appropriately. They might cause an elevation in CSF protein and, in rare cases, hemorrhage.

Rare Diagnoses

  • Coagulopathy: Disorders affecting blood clotting could lead to spontaneous hemorrhage into the CSF, resulting in elevated RBCs and potentially protein elevation due to the body's response to the hemorrhage.
  • CNS Vasculitis: Inflammation of the blood vessels within the CNS is a rare condition that could potentially cause both elevated protein in the CSF and hemorrhage due to the damage of the blood vessels.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.