What is the dose and duration of naproxen (nonsteroidal anti-inflammatory drug) for a patient switching from ibuprofen (nonsteroidal anti-inflammatory drug) 2 tablets twice daily (Bid)

Naproxen Dosing When Switching from Ibuprofen

For a patient switching from ibuprofen 2 tablets twice daily to naproxen, the recommended dose is 500 mg twice daily (every 12 hours) for 2-4 weeks, with potential tapering based on symptom response. 1, 2

Dosage Recommendation

• Naproxen 500 mg twice daily (every 12 hours) is the appropriate dosage when switching from ibuprofen 800 mg twice daily 1, 2
• For prescription naproxen, the standard dosage is 375-500 mg twice daily 1, 2
• For over-the-counter naproxen sodium (Aleve), the equivalent dosage would be 440 mg (2 tablets of 220 mg) twice daily 1

Duration of Treatment

• Initial treatment should be for 2-4 weeks at maximum tolerated and approved dosage 1
• After 2-4 weeks, evaluate treatment response 1
• If sufficient response is achieved, treatment can be continued with consideration for tapering after 12 weeks of sustained response 1
• The lowest effective dose should be used for the shortest duration consistent with individual treatment goals 2

Monitoring and Follow-up

• Assess response to treatment at 2-4 weeks 1
• If response is insufficient at 2-4 weeks, consider switching to another NSAID or adding second-line treatments 1
• For long-term use, monitor for potential side effects with baseline and periodic (every 3 months) assessment of:
  • Blood pressure
  • Renal function (BUN, creatinine)
  • Liver function tests
  • Complete blood count
  • Fecal occult blood 1

Precautions and Side Effects

• Common side effects include dyspepsia and GI discomfort (10-20% of patients) 1
• Consider gastroprotection with a proton pump inhibitor or H2 blocker in high-risk patients 1
• Use with caution in patients with:
  • Age over 60 years
  • History of peptic ulcer disease
  • Renal impairment
  • Cardiovascular disease
  • Concomitant use of anticoagulants 1
• Discontinue if:
  • BUN or creatinine doubles
  • Hypertension develops or worsens
  • Liver function tests increase to three times the upper limit of normal
  • GI bleeding occurs 1

Switching Considerations

• No washout period is required when switching from ibuprofen to naproxen 3
• Naproxen has a longer half-life than ibuprofen, allowing for twice-daily dosing compared to ibuprofen's three to four times daily dosing 4, 5
• Short-term use (7-10 days) of naproxen at non-prescription doses has a safety profile similar to placebo 6

Special Populations

• For elderly patients, consider starting at a lower dose and titrating upward as needed 2, 4
• Dose adjustment is not usually required for mild renal or hepatic impairment, but starting at a lower dose is prudent 2, 4
• Naproxen is not recommended for patients with moderate to severe renal impairment (creatinine clearance <30 mL/min) 2

Remember that the goal of NSAID therapy is to provide adequate pain relief and anti-inflammatory effects while minimizing potential adverse effects through appropriate dosing and duration of treatment.