From the Research
Mechanism of Intrarectal Absorption of Sorbitol
- The mechanism of drug absorption from the rectum is probably no different from that in the upper part of the gastrointestinal tract, despite the fact that the physiological circumstances differ substantially 1.
- There is no direct evidence on the mechanism of intrarectal absorption of sorbitol, but studies on intestinal absorption of sorbitol in rats suggest that it is a passive process that proceeds at a low rate 2.
- The absorption of sorbitol from the rectum may be influenced by factors such as the formulation of the suppository, the use of surfactants or other additives, and the particle size of the active ingredient 1.
Factors Affecting Sorbitol Absorption
- The concentration of sorbitol in the solution can affect its absorption, with higher concentrations leading to greater malabsorption 3, 4.
- The amount of sorbitol ingested can also affect its absorption, with larger amounts leading to greater malabsorption and symptoms of intolerance 3, 4.
- The presence of other substances, such as glucose or sucrose, can affect the absorption of sorbitol, but the exact mechanisms are not well understood 2.
Clinical Significance of Sorbitol Malabsorption
- Sorbitol malabsorption is a common finding in patients with functional abdominal discomfort, and dietary intervention can positively affect abdominal symptoms in these patients 5.
- Sorbitol malabsorption can lead to symptoms of carbohydrate intolerance, including gas, bloating, cramps, and diarrhea 3, 4.
- The evaluation of patients with functional gastrointestinal complaints should include careful inquiry into the use of products containing sorbitol 4.