Managing Missed Sertraline Doses
If you've missed 5 days of sertraline, take your regular dose immediately and continue your normal dosing schedule, but be aware you may experience discontinuation symptoms that should be monitored closely.
Immediate Actions
- Take your regular dose of sertraline as soon as possible 1
- Continue taking the remaining pills at your usual time (even if it means taking two pills on the same day if your next scheduled dose is approaching) 2
- Be prepared for possible discontinuation symptoms which may include anxiety, irritability, mood changes, headache, sweating, nausea, dizziness, electric shock-like sensations, and confusion 1
Discontinuation Syndrome
Sertraline has been associated with a discontinuation syndrome when doses are missed or the medication is abruptly stopped. This is particularly common with shorter-acting SSRIs like sertraline 2. Symptoms may include:
- Dizziness, fatigue, lethargy, general malaise 2
- Myalgias, chills, headaches 2
- Nausea, vomiting, diarrhea 2
- Insomnia, imbalance, vertigo 2
- Sensory disturbances, paresthesias 2
- Anxiety, irritability, and agitation 2
Monitoring and Precautions
- Monitor for signs of discontinuation syndrome over the next few days 1
- If symptoms are severe or concerning, contact your healthcare provider 1
- Do not attempt to drive or operate heavy machinery if you experience dizziness, sleepiness, or impaired thinking 1
- Avoid alcohol while restarting sertraline as it may worsen side effects 1
Long-term Considerations
- Consider discussing with your healthcare provider strategies to prevent missed doses in the future 2
- For some patients, medication organizers or reminder systems may be helpful 2
- Be aware that sertraline typically requires consistent administration for optimal therapeutic effect 2
Important Cautions
- Never abruptly stop taking sertraline without medical supervision 1
- If you frequently miss doses, discuss this with your healthcare provider as it may affect the medication's effectiveness 2
- If you experience severe symptoms such as suicidal thoughts, significant mood changes, or severe physical symptoms, seek immediate medical attention 1