What are 5 hours (h) and 5 causes (ts) of Intensive Care Unit (ICU) death?

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Last updated: March 25, 2025View editorial policy

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From the Research

The 5 Hs and 5 Ts represent the most common reversible causes of death in the ICU setting, and identifying them promptly is crucial to improve patient outcomes, as supported by the most recent study 1. The 5 Hs are:

  • Hypoxia (insufficient oxygen)
  • Hypovolemia (low blood volume)
  • Hydrogen ion excess (acidosis)
  • Hypo/Hyperkalemia (abnormal potassium levels)
  • Hypothermia The 5 Ts are:
  • Tension pneumothorax (collapsed lung)
  • Tamponade (cardiac compression)
  • Toxins (drug overdose or poisoning)
  • Thrombosis (pulmonary embolism or coronary thrombosis)
  • Trauma When a patient deteriorates in the ICU, healthcare providers should rapidly assess for these conditions as they are potentially reversible if identified quickly, as highlighted in the study 2.

Importance of Prompt Identification

Treatment depends on the specific cause identified - for example, hypoxia requires oxygen supplementation and ventilatory support, hypovolemia needs fluid resuscitation, tension pneumothorax requires needle decompression followed by chest tube placement, and cardiac tamponade may need pericardiocentesis. These causes are particularly important to remember during cardiac arrest situations, as addressing the underlying cause is essential for successful resuscitation, as noted in the study 3.

Regular Monitoring

Regular monitoring of vital signs, laboratory values, and clinical assessment helps identify these conditions before they progress to cardiac arrest, which is critical in reducing morbidity, mortality, and improving quality of life, as emphasized in the study 4.

ICU Care

Providing terminal care in the ICU creates significant personal and professional struggles among ICU nurses, as reported in the study 5, highlighting the need for support and resources to improve terminal care in the ICU setting.

Key Considerations

In the context of real-life clinical medicine, it is essential to prioritize the identification and management of the 5 Hs and 5 Ts to reduce morbidity, mortality, and improve quality of life, as supported by the most recent and highest quality study 1.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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