How do you manage a severe epistaxis?

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Last updated: October 19, 2025View editorial policy

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Management of Severe Epistaxis (Nosebleed)

The most effective first-line treatment for a profuse nosebleed is firm sustained compression to the lower third (soft part) of the nose for at least 10-15 minutes while sitting upright with the head slightly tilted forward. 1, 2

Initial Management

  • Position the patient sitting upright with head slightly tilted forward to prevent blood from entering the airway or stomach 3, 2
  • Apply firm sustained compression to the lower third (soft part) of the nose for at least 10-15 minutes without checking if bleeding has stopped 1, 2
  • The patient should breathe through their mouth and spit out any blood rather than swallow it 3
  • This approach alone resolves 90-95% of nosebleeds in most cases 4

If Bleeding Persists After Initial Compression

  • Clear any blood clots from the nose 3
  • Apply a topical vasoconstrictor such as oxymetazoline or phenylephrine spray (2 sprays in the bleeding nostril) 1, 2, 5
  • Resume compression for another 5-10 minutes 3
  • This approach resolves 65-75% of epistaxis cases that don't stop with compression alone 2, 5

Identifying the Bleeding Site

  • If bleeding continues, perform anterior rhinoscopy to identify the source of bleeding after removing any blood clots 1
  • When the bleeding site is identified, appropriate interventions may include:
    • Topical vasoconstrictors (as mentioned above) 1, 2
    • Nasal cautery (after proper anesthesia of the site) 1, 5
    • Moisturizing or lubricating agents 1, 3

Advanced Management (If Initial Measures Fail)

  • If bleeding continues despite the above measures, nasal packing should be considered 1
  • For severe cases requiring advanced intervention, refer to an otolaryngologist who can perform:
    • Nasal endoscopy to identify difficult-to-visualize bleeding sites 1, 2
    • More definitive treatments such as endoscopic cauterization or arterial ligation 2, 5
    • Tranexamic acid may be considered as it promotes hemostasis in 78% of patients versus 35% with oxymetazoline alone 5, 6

Special Considerations

  • For patients on anticoagulants or antiplatelet medications, do not discontinue these medications as first-line treatment 1, 3
  • In the absence of life-threatening bleeding, initiate the standard first-line treatments before considering transfusion, reversal of anticoagulation, or withdrawal of anticoagulant/antiplatelet medications 1, 7
  • For patients with recurrent epistaxis, prevention is key - apply petroleum jelly or other lubricating agents to keep the nasal mucosa moist 3, 2

When to Seek Emergency Care

  • If bleeding does not stop after 15 minutes of continuous pressure 3, 2
  • If the patient experiences dizziness, lightheadedness, or signs of significant blood loss 2
  • If bleeding is severe (duration >30 minutes over a 24-hour period) 1, 2
  • If the patient shows signs of hemodynamic instability such as tachycardia or hypotension 1, 2

Common Pitfalls to Avoid

  • Insufficient compression time - compression must be maintained continuously for at least 10-15 minutes 3, 2
  • Tilting the head backward, which can cause blood to flow into the throat and be aspirated 3, 4
  • Checking too frequently if bleeding has stopped, which disrupts clot formation 2
  • Neglecting prevention of recurrence by not addressing underlying nasal mucosa dryness 3, 2

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Guideline

Management of Nasal Epistaxis

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Guideline

Management of Epistaxis in Patients on Ozempic (Semaglutide)

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Research

Epistaxis Treatment Options: Literature Review.

Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India, 2023

Research

Tranexamic acid for patients with nasal haemorrhage (epistaxis).

The Cochrane database of systematic reviews, 2018

Guideline

Manejo de Epistaxis Relacionada con Apixaban

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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