Augmentin DDS Syrup Dosage for Adults and Children Over 12 Years
The typical dosage of Augmentin (amoxicillin/clavulanate) DDS syrup for adults and children over 12 years of age with normal renal function is 375 mg three times daily for most bacterial infections. 1
General Dosing Guidelines
- For adults and children over 12 years with normal renal function, Augmentin DDS syrup is typically administered as 375 mg three times daily 1
- The syrup formulation contains amoxicillin and clavulanic acid in a 4:1 ratio (amoxicillin:clavulanate) 2
- The medication should be taken with meals to improve gastrointestinal tolerance 3
Indication-Specific Dosing
Respiratory Tract Infections
- For community-acquired respiratory tract infections including sinusitis, acute otitis media, and community-acquired pneumonia, the standard dose of 375 mg three times daily is recommended 3
- For more severe respiratory infections or areas with high prevalence of resistant S. pneumoniae, higher doses may be considered 3
Skin and Soft Tissue Infections
- For uncomplicated skin and soft tissue infections, 375 mg three times daily is typically sufficient 1
- For complicated skin and soft tissue infections, particularly those potentially involving MRSA, additional or alternative antibiotics may be needed 4
Urinary Tract Infections
- For urinary tract infections, including those caused by amoxicillin-resistant organisms, 375 mg three times daily has shown approximately 70% success rate 1
Special Considerations
Duration of Treatment
- Treatment duration typically ranges from 7-14 days depending on the type and severity of infection 3
- Complete the full course of antibiotics even if symptoms improve before completion 3
Renal Impairment
- Dosage adjustment is required for patients with renal impairment 5
- For patients with creatinine clearance 10-30 mL/min, reduce dosing frequency to twice daily 5
- For patients with creatinine clearance <10 mL/min, reduce dosing frequency to once daily 5
Administration Guidelines
- Shake the suspension well before each use 2
- Take with food to minimize gastrointestinal side effects 3
- Store the reconstituted suspension in the refrigerator and discard after 10 days 5
Common Side Effects
- Gastrointestinal disturbances (diarrhea, nausea, vomiting) are the most common side effects 6
- Diarrhea is generally less frequent with twice-daily dosing compared to three-times-daily dosing 6
- Skin rash may occur, particularly in patients with mononucleosis 5
Clinical Pearls
- Augmentin provides coverage against beta-lactamase-producing organisms that would otherwise be resistant to amoxicillin alone 3
- The combination is particularly valuable for treating infections caused by multiply resistant bacteria 1
- For severe infections or those caused by less susceptible organisms, higher doses or alternative antibiotics may be necessary 3