Differential Diagnosis for Ana Negative with Butterfly Appearance
- Single most likely diagnosis
- Systemic Lupus Erythematosus (SLE): Although Ana is negative, the presence of a butterfly-shaped rash is highly suggestive of SLE. The negative Ana result does not rule out SLE, as some patients may have a negative test, especially early in the disease.
- Other Likely diagnoses
- Dermatomyositis: This condition can cause a similar butterfly-shaped rash, as well as muscle weakness.
- Sjögren's syndrome: Although less common in teenagers, Sjögren's can cause a variety of skin rashes, including a butterfly-shaped one.
- Rosacea: This condition can cause a butterfly-shaped rash on the face, but it is typically accompanied by other symptoms such as acne and flushing.
- Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
- Sarcoidosis: This condition can cause a variety of skin rashes, including a butterfly-shaped one, and can be life-threatening if left untreated.
- Lymphoma: Some types of lymphoma can cause skin rashes, including a butterfly-shaped one, and require prompt treatment.
- Rare diagnoses
- Relapsing polychondritis: This condition can cause a variety of skin rashes, including a butterfly-shaped one, and is often accompanied by other symptoms such as joint pain and eye inflammation.
- Mixed connective tissue disease: This condition can cause a variety of symptoms, including a butterfly-shaped rash, and is often accompanied by other symptoms such as muscle weakness and joint pain.