From the Guidelines
I strongly advise against using Rejuvenx (Polydeoxyribonucleotide, PDRN) cream without consulting a dermatologist due to the lack of sufficient clinical evidence supporting its effectiveness. The available evidence does not provide a clear recommendation for the use of PDRN cream in wound healing or skin regeneration. A study from 2016 1 discusses the use of various interventions to enhance the healing of chronic ulcers of the foot in diabetes, but it does not provide strong evidence to support the use of PDRN cream. Some key points to consider when evaluating the use of PDRN cream include:
- The lack of high-quality clinical trials specifically evaluating the effectiveness of Rejuvenx PDRN cream
- The potential benefits of PDRN in skin regeneration and wound healing, such as improved skin hydration and reduced inflammation, are based on limited studies and may not be applicable to this specific product
- The importance of consulting with a dermatologist to determine the best course of treatment for individual skin concerns and medical history. It is essential to prioritize evidence-based treatments and consult with a healthcare professional before using any new product, especially one with limited clinical evidence supporting its use.
From the Research
Overview of Rejuvenx (Polydeoxyribonucleotide, PDRN) Cream
- Rejuvenx cream is a product containing Polydeoxyribonucleotide (PDRN), a DNA-derived drug extracted from the sperm cells of Oncorhynchus mykiss or O. keta 2.
- PDRN exhibits wound healing and anti-inflammatory activities by activating adenosine A2A receptor and salvage pathways 3.
Wound Healing Effects
- A study compared the wound healing effects of O. keta-derived PDRN cream (Rejuvenex Cream) with those of O. mykiss-derived PDRN injection (Placentex) and found that the wound healing effects were similar between the O. keta-derived PDRN injection and O. mykiss-derived PDRN injection groups, followed by the O. keta-derived cream and normal saline soaked dressing groups 4.
- The injection of PDRN extracted from O. keta was found to be as effective at healing full-thickness skin defects as the O. mykiss-derived PDRN injection, which is currently used in the clinic 4.
Anti-Inflammatory Effects
- PDRN has anti-inflammatory effects, which are mediated by the inhibition of nitric oxide production and inducible nitric oxygen synthase protein expression by suppressing phosphorylation of p38 and ERK, without cytotoxicity 2.
- PDRN also promotes cell proliferation and collagen production in human dermal fibroblast 2.
Cosmeceutical Applications
- PDRN has been recognized for its potential in cosmeceuticals due to its anti-aging and wound healing properties 5.
- The bioactivities of PDRN regarding cosmeceuticals are elucidated comprehensively, including its effects on skin regeneration and tissue repair 5.