Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: October 20, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

Differential Diagnosis for Lower Abdominal Pain with Fever

Single Most Likely Diagnosis

  • Appendicitis: This is often the first consideration for lower abdominal pain accompanied by fever, especially if the pain initially presents around the navel and then shifts to the lower right abdomen. The fever can indicate an infectious or inflammatory process, which aligns with appendicitis.

Other Likely Diagnoses

  • Urinary Tract Infection (UTI): Lower abdominal pain and fever can be symptoms of a UTI, particularly if the infection has moved up to the kidneys (pyelonephritis). The presence of dysuria, frequent urination, or cloudy urine can support this diagnosis.
  • Diverticulitis: Inflammation of the diverticula in the colon can cause lower abdominal pain, usually on the left side, accompanied by fever. This condition is more common in older adults.
  • Ovarian Cyst or Torsion: In females, a ruptured ovarian cyst or ovarian torsion can cause severe lower abdominal pain and may be accompanied by fever if there's an associated infection.

Do Not Miss Diagnoses

  • Ectopic Pregnancy: Although less common, an ectopic pregnancy can present with lower abdominal pain and fever, especially if there's associated bleeding or rupture. This is a medical emergency.
  • Perforated Viscus: A hole in the wall of the stomach or intestine can lead to peritonitis, an infection of the abdominal cavity, causing severe pain and fever. Prompt surgical intervention is necessary.
  • Inflammatory Bowel Disease (IBD) Flare: Conditions like Crohn's disease or ulcerative colitis can cause lower abdominal pain and fever during a flare-up.

Rare Diagnoses

  • Endometriosis: While not typically associated with fever, severe endometriosis can cause lower abdominal pain and, in rare cases, may be accompanied by fever if there's an associated infection or abscess.
  • Tuberculosis: Abdominal tuberculosis can cause lower abdominal pain, fever, and other systemic symptoms. It's more common in areas where TB is prevalent.
  • Psoas Abscess: An abscess in the psoas muscle can cause lower abdominal or back pain and fever. It's often associated with a history of recent surgery, trauma, or infection.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.