What is the role of Vitamin E in the management of oral ulcers (mouth sores)?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: February 11, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

From the Research

Role of Vitamin E in Managing Oral Ulcers

  • Vitamin E has been studied for its potential role in managing oral ulcers, with some evidence suggesting its effectiveness in combination with other treatments 1.
  • A study published in 2022 found that a combination of mecobalamin and vitamin E was effective in treating recurrent oral ulcers, with significant improvements in pain levels, ulcer healing time, and quality of life 1.
  • The anti-inflammatory effects of vitamin E have also been investigated, with one study finding that it can inhibit key inflammatory pathways and downregulate inflammatory genes in response to Candida albicans 2.

Comparison with Other Vitamins

  • Other vitamins, such as vitamin B12, have also been studied for their potential role in managing oral ulcers, with some evidence suggesting their effectiveness in relieving pain and improving symptoms 3.
  • Vitamin D has also been investigated for its role in wound healing, including in the oral mucosa, with some evidence suggesting its effectiveness in promoting healing and reducing inflammation 4.
  • Vitamin B1, B2, and B6 deficiencies have also been identified as potential precipitating factors in recurrent aphthous ulceration, with replacement therapy showing significant clinical improvement in deficient patients 5.

Mechanisms of Action

  • The exact mechanisms of action of vitamin E in managing oral ulcers are not fully understood, but its anti-inflammatory effects are thought to play a key role 2.
  • Vitamin E may also have antioxidant effects, which could help to reduce oxidative stress and promote healing in the oral mucosa.
  • Further research is needed to fully understand the role of vitamin E in managing oral ulcers and to determine its potential as a therapeutic agent.

References

Research

The Effectiveness of Vitamin B12 for Relieving Pain in Aphthous Ulcers: A Randomized, Double-blind, Placebo-controlled Trial.

Pain management nursing : official journal of the American Society of Pain Management Nurses, 2015

Research

The Role of Vitamin D on the Wound Healing Process: A Case Series.

International medical case reports journal, 2023

Research

Recurrent aphthous ulceration: vitamin B1, B2 and B6 status and response to replacement therapy.

Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 1991

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.