What is the interaction between ivermectin and fenbendazole?

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Last updated: March 25, 2025View editorial policy

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From the Research

Ivermectin and fenbendazole should not be used together in humans due to the lack of established safety and efficacy data for this combination, and fenbendazole is not approved for human use. The provided evidence does not directly address the interaction between ivermectin and fenbendazole, but it highlights the importance of using approved medications for specific indications. Ivermectin is FDA-approved for treating certain parasitic infections in humans, including strongyloidiasis and onchocerciasis, typically at doses of 150-200 mcg/kg as a single dose or according to specific treatment protocols for the particular infection 1, 2, 3. Fenbendazole, however, is only approved for veterinary use and is not considered safe for human consumption, with no established human dosing regimens available 4, 5. Despite some social media claims, neither drug has proven effectiveness against cancer or viral infections like COVID-19. If you're concerned about parasitic infections, you should consult with a healthcare provider who can prescribe appropriate medications based on proper diagnosis. Self-medicating with veterinary drugs or using these medications for unapproved purposes carries significant health risks, including potential toxicity and dangerous drug interactions. The most recent and highest quality study 4 suggests that alternative and/or complementary treatment regimens are needed to eliminate onchocerciasis, but it does not support the use of fenbendazole in humans. Therefore, it is recommended to avoid using ivermectin and fenbendazole together in humans and instead follow established treatment protocols for parasitic infections. Key points to consider:

  • Ivermectin is FDA-approved for certain parasitic infections in humans
  • Fenbendazole is only approved for veterinary use and not considered safe for human consumption
  • No established human dosing regimens are available for fenbendazole
  • Self-medicating with veterinary drugs or using medications for unapproved purposes carries significant health risks
  • Consult with a healthcare provider for proper diagnosis and treatment of parasitic infections.

References

Research

Ivermectin treatment of onchocerciasis.

Australian and New Zealand journal of ophthalmology, 1989

Research

The status of ivermectin in the treatment of human onchocerciasis.

The American journal of tropical medicine and hygiene, 1989

Research

The effects of high-dose ivermectin regimens on Onchocerca volvulus in onchocerciasis patients.

Transactions of the Royal Society of Tropical Medicine and Hygiene, 1999

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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