Vulvovaginal Candidiasis (Yeast Infection): This is the most common cause of vaginal irritation, characterized by itching, burning, and a white, clumpy discharge. It's often associated with antibiotic use, diabetes, or immunosuppression.

Bacterial Vaginosis (BV): A bacterial infection that causes an imbalance in the natural vaginal flora, leading to symptoms like fishy odor, thin discharge, and irritation.
Trichomoniasis: A sexually transmitted infection caused by a parasite, resulting in symptoms such as itching, burning, redness, and a frothy discharge.
Atrophic Vaginitis: Common in postmenopausal women due to decreased estrogen levels, leading to vaginal dryness, itching, and irritation.
Contact Dermatitis: An allergic reaction or irritation from soaps, douches, or other products, causing redness, itching, and burning.

Herpes Simplex Virus (HSV): A sexually transmitted infection that can cause severe vaginal irritation, along with painful blisters or ulcers.
Syphilis: Another sexually transmitted infection with various stages, including a primary stage that can present with a painless sore, which might be missed if not properly examined.
Cervical Cancer: Although rare, it can cause vaginal irritation among other symptoms like abnormal vaginal bleeding. Early detection is crucial for effective treatment.

Lichen Sclerosus: A chronic skin condition that can affect the vulva, causing itching, pain, and scarring if left untreated.
Lichen Planus: An autoimmune condition that can affect the mucous membranes, including the vagina, leading to irritation and discomfort.
Desquamative Inflammatory Vaginitis (DIV): A rare condition characterized by severe vaginal inflammation and a purulent discharge, often resistant to standard treatments.