What are the recommendations for patients following S2K (Society for Clinical and Economic Studies of Complementary Medicine) guidelines?

S2k Guidelines Recommendations for Patient Management

The S2k guidelines do not appear to exist as a unified set of clinical recommendations from the Society for Clinical and Economic Studies of Complementary Medicine, but rather represent a specific classification of German clinical practice guidelines based on methodological rigor.

Understanding S2k Guidelines

S2k guidelines represent a specific classification in the German Association of the Scientific Medical Societies (AWMF) methodological framework, where:

• S2k indicates guidelines developed through a formal consensus method with a representative panel of experts 1
• These guidelines are more rigorous than S1 guidelines (informal consensus) but do not require the systematic literature review of S2e or S3 guidelines 1
• The "k" in S2k stands for "konsensus" (consensus), emphasizing the formal consensus-building process 1

Recent S2k Guidelines in Various Medical Fields

Several recent S2k guidelines have been published in specific medical areas:

• Hidradenitis Suppurativa/Acne Inversa: These guidelines classify the disease into inflammatory and predominantly non-inflammatory forms, with treatment recommendations including oral tetracyclines, intravenous clindamycin, biologics (adalimumab, secukinumab, bimekizumab), and surgical procedures based on disease severity 2, 3

• Localized Scleroderma: Treatment recommendations include topical corticosteroids for limited involvement, UV therapy, and systemic therapy with methotrexate for severe skin or musculoskeletal involvement 4

• Lipedema: Guidelines focus on diagnostic criteria, differential diagnoses, and treatment options including conservative and surgical approaches 5

• Deep Vein Thrombosis: Management includes standardized diagnostic algorithms combining clinical probability assessment, D-dimer testing, and imaging, with anticoagulation therapy favoring direct oral anticoagulants 6

Sick Day Medication Guidance

S2k consensus recommendations for sick day medication guidance for patients with diabetes, kidney, or cardiovascular disease include:

• Trigger symptoms for implementing sick day medication guidance:

  • Vomiting or diarrhea resulting in significant fluid losses 1
  • Anorexia or nausea causing significant decrease in fluid intake 1
  • New lightheadedness, dizziness, or fainting 1

• Medications to temporarily stop during acute illness:

  • SGLT2 inhibitors 1
  • NSAIDs 1
  • Potassium-sparing diuretics 1
  • Loop diuretics 1
  • ACE inhibitors/ARBs 1
  • Thiazide/thiazide-like diuretics 1

• Duration of medication hold:

  • Up to 3 days or until symptoms resolve 1
  • Resume medications at usual doses within 24-48 hours of eating and drinking normally 1

Mechanical Circulatory Support Guidelines

For patients with mechanical circulatory support devices:

• Emergency medical service providers should transport the patient's backup and peripheral equipment 1
• Doppler probe and manual cuff should be used to obtain blood pressure 1
• Outpatients with device stoppage should not have the device restarted without guidance from the primary MCS center 1
• Device parameters (power, speed, flow, pulsatility) should be recorded throughout the patient's course 1

Hypertension Management Guidelines

The International Society of Hypertension provides recommendations for hypertension management:

• Diagnosis: Office BP ≥140/90 mmHg indicates hypertension, particularly if home BP ≥135/85 mmHg or 24h ambulatory BP ≥130/80 mmHg 1

• Treatment approach:

  • For Grade 1 hypertension (140-159/90-99 mmHg): Start lifestyle interventions and drug treatment in high-risk patients or after 3-6 months of lifestyle intervention in others 1
  • For Grade 2 hypertension (≥160/100 mmHg): Start drug treatment immediately 1

• Medication algorithm:

  • For non-black patients: Start with low dose ACEI/ARB, increase to full dose, add thiazide/thiazide-like diuretic 1
  • For black patients: Start with low dose ARB + DHP-CCB or DHP-CCB + thiazide/thiazide-like diuretic 1

• Target: Reduce BP by at least 20/10 mmHg; ideally to <130/80 mmHg, individualized for elderly based on frailty 1

Chronic Coronary Syndrome Management

The European Society of Cardiology provides recommendations for chronic coronary syndrome management:

• Lifestyle counselling should include:

  • Vaccination against influenza, pneumococcal disease, and other widespread infections 1
  • Treatment of sleep-related breathing disorders 1
  • Avoidance of psychosocial stress 1
  • Smoking cessation with pharmacological and behavioral strategies 1

• Risk factor targets:

  • LDL-C goal <1.4 mmol/L (55 mg/dL) and ≥50% reduction from baseline 1
  • HbA1c <7.0% (53 mmol/mol) 1
  • SBP 120-129 mmHg if well tolerated 1
  • Mediterranean diet high in vegetables, fruits, and wholegrains 1
  • 30-60 minutes of moderate activity >5 days/week 1

Common Pitfalls and Caveats

• S2k guidelines may vary in quality and rigor compared to S3 guidelines which include both formal consensus and systematic evidence review 1
• Implementation of S2k guidelines should consider local healthcare system resources and capabilities 1
• Patient education is essential for adherence to guideline recommendations 1
• Medication adjustments during acute illness should be time-limited and patients should be instructed when to seek medical help 1
• Guidelines should be applied with consideration of individual patient circumstances and preferences 1