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Last updated: October 21, 2025View editorial policy

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Differential Diagnosis for Right Testicular Pain

  • Single most likely diagnosis
    • Epididymitis: This is the most common cause of acute testicular pain, often resulting from bacterial infection, typically affecting young men.
  • Other Likely diagnoses
    • Orchitis: Inflammation of one or both testicles, usually caused by bacterial or viral infections.
    • Testicular torsion (early stages): Although it's a medical emergency, in its early stages, it might not present with the classic severe pain and can be mistaken for other conditions.
    • Varicocele: Enlargement of the veins within the scrotum, similar to varicose veins, which can cause aching or discomfort.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
    • Testicular torsion: A surgical emergency that requires immediate attention to save the affected testicle and preserve fertility.
    • Testicular cancer: Although less common, it's crucial to rule out, especially in men with a history of undescended testes or family history of testicular cancer.
    • Appendicitis (with an atypical presentation): Rarely, appendicitis can present with testicular pain if the appendix is located near the testicles.
  • Rare diagnoses
    • Henoch-Schönlein purpura: A form of vasculitis that can cause testicular pain among other symptoms like rash and joint pain.
    • Polyarteritis nodosa: A systemic vasculitis that can affect various organs, including the testicles, causing pain.
    • Spermatocele or epididymal cyst: Benign cysts that can cause discomfort or pain, especially if they become large or infected.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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