Differential Diagnosis for Small Amount of Fluid in Uterine Cavity in a 66-Year-Old Female

Single Most Likely Diagnosis

• Endometrial atrophy or thinning: This is a common finding in postmenopausal women due to the decrease in estrogen levels, which can lead to a small amount of fluid accumulation in the uterine cavity.

Other Likely Diagnoses

• Endometrial polyp: These are growths in the lining of the uterus that can cause bleeding and fluid accumulation, especially in postmenopausal women.
• Endometrial hyperplasia: A condition where the lining of the uterus grows too thick, which can lead to fluid accumulation and bleeding.
• Cervical stenosis: Narrowing of the cervical canal can cause fluid to accumulate in the uterine cavity.

Do Not Miss Diagnoses

• Endometrial cancer: Although less likely, it is crucial to rule out cancer, especially in postmenopausal women, as it can present with abnormal uterine bleeding or fluid accumulation.
• Pyometra: An accumulation of pus in the uterine cavity, often associated with infection, which can be life-threatening if not treated promptly.

Rare Diagnoses

• Uterine sarcoma: A rare type of cancer that originates in the muscle and supporting tissues of the uterine walls.
• Metastatic disease to the uterus: Rarely, cancers from other parts of the body can metastasize to the uterus, leading to fluid accumulation or other symptoms.