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Last updated: October 21, 2025View editorial policy

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Differential Diagnosis for Inflamed Prepuce

  • Single most likely diagnosis
    • Balanitis: This is an inflammation of the glans penis and is often associated with an inflamed prepuce. It can be caused by poor hygiene, infections (bacterial, fungal, or viral), or allergic reactions. The prepuce not being tight suggests that the inflammation is not due to a condition like phimosis, making balanitis a plausible diagnosis.
  • Other Likely diagnoses
    • Posthitis: Inflammation of the prepuce itself, which can occur due to similar reasons as balanitis, including infections or allergic reactions. The symptoms can overlap with balanitis, and the condition might occur concurrently.
    • Contact Dermatitis: An allergic reaction or irritation from soaps, condoms, or other products can cause inflammation of the prepuce. This condition is common and can easily explain the symptoms described.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
    • Gangrene or Fournier's Gangrene: Although rare, this is a severe condition involving necrotizing fasciitis of the genitalia. Early signs might include inflammation and pain, and it requires immediate medical attention to prevent severe outcomes.
    • Sexually Transmitted Infections (STIs): Certain STIs, like syphilis or herpes, can cause genital inflammation. Missing these diagnoses could lead to serious health consequences, including transmission to others and long-term health issues.
  • Rare diagnoses
    • Lichen Sclerosus: A chronic inflammatory skin condition that can affect the genital area, leading to inflammation and potentially causing the prepuce to appear inflamed. It's less common but should be considered in cases where other diagnoses are ruled out.
    • Psoriasis or Eczema: These skin conditions can occasionally affect the genital area, including the prepuce, leading to inflammation. They are less likely causes of isolated preputial inflammation but should be considered in patients with a history of these conditions.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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