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Last updated: October 22, 2025View editorial policy

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Differential Diagnosis for Back of Knee Pain Post Trauma

Single Most Likely Diagnosis

  • Hematoma or Contusion: This is the most likely diagnosis given the history of trauma. A direct blow to the back of the knee can cause bleeding into the soft tissues, leading to a hematoma or contusion, which presents as pain, swelling, and bruising.

Other Likely Diagnoses

  • Baker's Cyst Rupture: Trauma can cause a pre-existing Baker's cyst to rupture, leading to pain and swelling in the back of the knee.
  • Muscle Strain: The muscles at the back of the knee, such as the hamstring or popliteus, can be strained due to the trauma, causing pain and limited mobility.
  • Ligament Sprain: The ligaments around the knee, including those at the back, can be sprained due to trauma, leading to instability and pain.

Do Not Miss Diagnoses

  • Popliteal Artery Injury: Although less common, a severe trauma can cause injury to the popliteal artery, which runs at the back of the knee. This is a medical emergency that requires prompt intervention to prevent limb loss.
  • Deep Vein Thrombosis (DVT): Trauma can increase the risk of DVT, especially if there is significant swelling or immobilization. DVT can be life-threatening if it leads to a pulmonary embolism.
  • Fracture: Certain fractures, such as a tibial plateau fracture or a fracture of the fibula, can present with pain at the back of the knee after trauma.

Rare Diagnoses

  • Ganglion Cyst: Although rare, a ganglion cyst can form at the back of the knee and cause pain, especially if it becomes large enough to compress nearby structures.
  • Tumors: Tumors, either benign or malignant, can cause pain at the back of the knee, but this would be extremely rare as a direct result of trauma.
  • Infection: In rare cases, trauma can introduce bacteria into the tissues, leading to an infection such as cellulitis or abscess formation at the back of the knee.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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