What is the treatment for infiltration?

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Treatment of Infiltration in Vascular Access

For any size infiltration, apply ice for at least 10 minutes and avoid maximizing blood pump speed. 1

Management Based on Severity

Small Infiltration

  • Apply ice for a minimum of 10 minutes to help decrease pain, reduce the size of infiltration, and potentially decrease bleeding time 1
  • Refrain from maximizing blood pump speed to prevent further damage 1
  • Monitor closely for signs and symptoms of worsening infiltration 1

Moderate Infiltration

  • Withdraw the needle and hold manual pressure over the infiltration site 1
  • Apply ice for at least 10 minutes 1
  • If infiltration occurs after heparin administration, take care to properly clot the needle tract without clotting the fistula 1
  • In some cases, leaving the needle in place and cannulating another site may be appropriate 1

Large Infiltration

  • Withdraw the needle and apply manual pressure 1
  • Apply ice for at least 10 minutes 1
  • Determine if dialysis is necessary that day 1
  • If dialysis is required:
    • Cannulate a site proximal to the infiltration injury 1
    • If proximal cannulation is not possible, wait 30 minutes with manual pressure and ice before reattempting at the area of injury 1
  • Consider resting the fistula for at least one treatment if possible 1

Assessment After Infiltration

  • Perform close assessment of the site, the AV access, and the adjacent extremity 1
  • Measure the extent of swelling 1
  • Assess the presence of flow in the AV access both proximal and distal to the hematoma 1
  • Evaluate circulation to the associated extremity 1
  • Monitor for potential complications such as hematoma formation 1

Complications of Infiltration

  • Hematoma development can vary from small diffuse areas to large firm masses that may compress vessels 1
  • Significant hematomas can lead to:
    • Thrombosis of the AV access 1
    • Development of stenosis at the site 1
    • Need for central venous catheter placement 1
    • Delayed use of the access for up to 3 months 1
  • A single infiltration injury before successful cannulation is associated with 56% lower odds of overall AVF maturation 1

Prevention of Further Damage

  • Use ultrasound guidance to help determine direction of flow and proper needle placement in select patients when performed by trained operators 1
  • For future cannulations, select a site above the infiltration if the fistula must be used 1
  • If the patient has a catheter in place, consider restarting fistula use with one needle and gradually advancing to two needles, larger needle size, and greater blood flow rates as the access allows 1
  • Ensure proper needle removal technique to prevent post-dialysis infiltrations 1
    • Apply gauze dressing over the needle site without applying pressure initially
    • Remove the needle at approximately the same angle as insertion
    • Only apply pressure after the needle is completely removed

Common Pitfalls to Avoid

  • Lifting up on the needle after it is in the vein, which can cause infiltration 1
  • Improper needle flip or taping procedures that may lead to infiltration 1
  • Using too steep an angle during needle removal, which may cause the needle's cutting edge to puncture the vein wall 1
  • Applying pressure to the puncture site before the needle is completely removed 1
  • Failing to recognize early signs of infiltration, which can lead to more extensive damage 1, 2

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

IV therapy: recognizing the differences between infiltration and extravasation.

British journal of nursing (Mark Allen Publishing), 2008

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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