Zepbound (Tirzepatide) 7.5 mg Auto-injector Dosage Instructions
Zepbound 7.5 mg subcutaneous solution should be administered once weekly using the auto-injector device, injected into the abdomen, thigh, or upper arm.
Administration Instructions
- Zepbound is administered via subcutaneous injection once weekly, on the same day each week 1
- The auto-injector should be used to inject into the abdomen, thigh, or upper arm, rotating injection sites with each dose 2
- The entire contents of the 7.5 mg auto-injector should be administered as a single dose 3
- The maximum recommended subcutaneous injection volume is generally 1.5 mL, though volumes up to 3.5 mL may be considered in certain circumstances 4
Dosing Considerations
- The 7.5 mg dose is typically part of a dose escalation regimen for patients with type 2 diabetes or those using the medication for weight management 5
- No dosage adjustment is required for patients with renal impairment, including those with eGFR ≥20 mL/min per 1.73 m² 5
- For patients with severe renal impairment (eGFR <30 mL/min), careful monitoring is recommended due to potential delayed drug clearance 5
Potential Adverse Effects
- Gastrointestinal effects are the most commonly reported adverse events, including nausea, vomiting, diarrhea, and constipation 6
- Headache, joint pain, and fatigue may also occur during treatment 6
- In rare cases, more serious adverse events such as pancreatitis have been reported 6
- There have been case reports of functional small bowel obstruction, even in patients without predisposing factors 1
Important Administration Tips
- The auto-injector should be allowed to warm to room temperature for approximately 30 minutes before injection 2
- Visually inspect the solution before administration - it should be clear and colorless to slightly yellow 3
- Do not use if particulate matter is visible or if the solution is cloudy or discolored 3
- The injection should be administered into healthy, non-irritated skin, avoiding areas that are bruised, red, or hard 2
Storage Requirements
- Store the auto-injector in the refrigerator (36°F to 46°F or 2°C to 8°C) 3
- Do not freeze the medication 3
- The auto-injector may be kept at room temperature (below 86°F or 30°C) for up to 21 days 3
Always follow the specific instructions provided with the medication packaging and consult with a healthcare provider for personalized guidance on administration.