From the Research
Elevated vitamin B12 levels are typically caused by consuming excessive amounts of B12 supplements, certain medical conditions, or macro-vitamin B12, and it is essential to evaluate these levels to rule out underlying conditions, as suggested by the most recent study 1. The causes of high vitamin B12 levels can be multifaceted, including:
- Consuming excessive amounts of B12 supplements
- Certain medical conditions, such as liver disease, kidney disease, and certain types of cancer
- Macro-vitamin B12, which can cause falsely elevated cobalamin levels
- Other factors, such as monoclonal gammapathy of undetermined significance, renal failure, and inflammatory or autoimmune diseases, as reported in earlier studies 2, 3, 4 It is crucial to note that high vitamin B12 levels can be associated with severe diseases, and early diagnosis is essential, as highlighted in a review 4. In children, high vitamin B12 values are usually benign, but some patients may develop leukemia later, emphasizing the need for follow-up, as shown in a study 5. The most critical step in managing elevated vitamin B12 levels is to evaluate the underlying cause and rule out any severe diseases, as recommended by the latest research 1.