Compatibility of Keppra (Levetiracetam) and Meclizine
Yes, Keppra (levetiracetam) and meclizine can be safely taken together as there are no significant drug interactions between these medications. 1, 2
Medication Overview
Levetiracetam (Keppra)
- Antiepileptic medication used for seizure disorders at doses of 1000-3000 mg/day for most adults 2
- Initial dose typically 500 mg twice daily for adults 2
- Does not significantly interact with other medications through the cytochrome P450 system 3
- Has a unique mechanism of action involving binding to synaptic vesicle protein 2A 3
- Common side effects include somnolence and fatigue 2, 4
Meclizine
- Antiemetic medication used to treat nausea and vomiting 1
- Has been shown to be effective in reducing nausea and vomiting in clinical trials 1
- Significantly reduces vomiting compared to placebo 1
Compatibility Analysis
Lack of Drug Interactions
- Levetiracetam has minimal metabolism and lacks cytochrome P450 isoenzyme-inducing potential 3
- Levetiracetam is not associated with clinically significant pharmacokinetic interactions with other drugs 3
- Unlike other antiepileptic medications (such as phenytoin, phenobarbital, carbamazepine), levetiracetam does not have significant drug interactions 1
Clinical Considerations
- Meclizine can be used as an antiemetic when needed, even in patients taking levetiracetam 1
- Both medications can cause some degree of sedation, so patients should be monitored for additive sedative effects 1, 4
- Levetiracetam is preferred over enzyme-inducing antiepileptic drugs (EIAEDs) when considering drug interactions 1
Patient Monitoring Recommendations
Side Effects to Monitor
- Watch for increased sedation or somnolence, as both medications can cause drowsiness 1, 4
- Monitor for dizziness, which can occur with either medication 3, 4
- Be aware of potential cognitive effects, though levetiracetam is not typically associated with significant cognitive impairment 3
Dosing Considerations
- No dose adjustments are needed when using these medications together 3
- Start with standard doses of each medication as clinically indicated 2
- For levetiracetam, dose adjustments may be needed based on renal function, not due to the combination with meclizine 2
Conclusion
The combination of levetiracetam (Keppra) and meclizine is safe with no significant drug interactions. This makes levetiracetam an advantageous choice among antiepileptic medications when antiemetics like meclizine are needed 1, 3. Patients should be monitored for potential additive sedative effects, but no specific dose adjustments are required when using these medications together 3, 4.