From the Research
Relationship between Guillain-Barré Syndrome and Thrombosis
- There is evidence to suggest a rare association between Guillain-Barré Syndrome (GBS) and thrombotic vascular events, such as cerebral venous thrombosis 1.
- A case report described a 28-year-old woman with active ulcerative colitis and no previous history of SARS-CoV-2 vaccination, who developed GBS and cerebral venous thrombosis 1.
- However, the exact relationship between GBS and thrombosis is not well understood and requires further investigation.
Inflammatory Proteins and GBS
- Research suggests that inflammatory proteins, such as IFN-γ, IL-7, SCGF-β, and Eotaxin, may be causally linked to the occurrence and development of GBS 2.
- A genome-wide Mendelian randomization analysis found that these inflammatory proteins were associated with an increased risk of GBS 2.
- However, the relationship between these inflammatory proteins and thrombosis in GBS patients is not clear.
Genetic Factors and GBS
- Genetic factors, such as human leukocyte antigen (HLA) alleles, have been associated with an increased risk of GBS 3.
- Abnormal expression of cytokine-coding genes has also been detected in GBS patients 3.
- However, the relationship between genetic factors and thrombosis in GBS patients is not well understood.
Thyroid Function and GBS
- Research suggests that abnormal thyroid function may be associated with increased disease severity and poor prognosis in GBS patients 4.
- Low levels of free triiodothyronine (FT3) have been found to be negatively correlated with disease severity in GBS patients 4.
- However, the relationship between thyroid function and thrombosis in GBS patients is not clear.
Complications of GBS
- GBS can be complicated by a range of conditions, including autoimmune diseases and thrombotic events 5.
- A good understanding of the complications of GBS is essential for clinicians to recognize and manage them properly 5.
- However, the relationship between GBS and thrombosis is not well understood and requires further investigation.