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Differential Diagnosis for Yellow Fingernails

Single Most Likely Diagnosis

  • Fungal infection of the nail (onychomycosis): This is the most common cause of yellowing nails due to the infection of the nail plate by fungi, leading to discoloration, thickening, and brittleness.

Other Likely Diagnoses

  • Psoriasis: Nail psoriasis can cause yellowing of the nails due to the buildup of skin cells under the nail plate.
  • Aging: As people age, their nails can become thicker, more brittle, and develop a yellowish hue.
  • Smoking: Smoking can cause yellowing of the nails due to the chemicals in tobacco.
  • Nail polish use: Frequent use of nail polish, especially without proper removal and nail care, can lead to yellowing of the nails.

Do Not Miss Diagnoses

  • Thyroid disease: Both hypothyroidism and hyperthyroidism can cause changes in nail color, including yellowing, due to metabolic changes affecting nail growth.
  • Diabetes: Diabetic patients may experience nail changes, including yellowing, due to high blood sugar levels affecting nail health.
  • Kidney disease: Certain kidney diseases can lead to changes in nail color, including yellowing, due to the buildup of toxins.
  • Liver disease: Liver conditions, such as jaundice, can cause a yellowish discoloration of the nails due to bilirubin buildup.

Rare Diagnoses

  • Yellow nail syndrome: A rare condition characterized by yellowing of the nails, lymphedema, and respiratory problems, often associated with chronic bronchitis or sinusitis.
  • Arsenic poisoning: Exposure to arsenic can cause a range of symptoms, including yellowing of the nails, due to its toxic effects on the body.
  • Vitamin deficiencies: Deficiencies in vitamins like B7 (biotin) can affect nail health, potentially leading to yellowing, although this is less common.

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Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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