How to Take Synthroid (Levothyroxine)
Synthroid (levothyroxine) should be taken as a single daily dose on an empty stomach, one-half to one hour before breakfast with a full glass of water, and at least 4 hours away from medications or supplements that can interfere with its absorption. 1
Proper Administration Guidelines
- Take Synthroid at the same time each day, preferably in the morning, to maintain consistent hormone levels 1
- Swallow the tablet with a full glass of water to avoid choking or gagging 1
- Wait at least 30-60 minutes before eating breakfast after taking Synthroid 1
- For patients who cannot swallow tablets (such as children), tablets can be crushed and suspended in a small amount of water (5-10 mL) and administered immediately 1
Avoiding Medication Interactions
- Take Synthroid at least 4 hours before or after taking:
- Avoid taking Synthroid with foods that may decrease absorption, such as soybean-based products 1
Special Considerations
- Hypothyroidism during pregnancy: Levothyroxine requirements often increase during pregnancy, requiring more frequent monitoring 4
- Elderly patients or those with cardiac disease: These patients may require lower doses and more gradual titration to avoid cardiac complications 4
- Patients with diabetes: Blood glucose levels should be monitored closely as thyroid hormone replacement may affect insulin requirements 1
Alternative Timing Options
- While morning administration is standard, some research suggests that bedtime intake may be effective and potentially improve thyroid hormone levels for some patients 5
- Discuss with your healthcare provider before changing the timing of your dose 5
Common Pitfalls to Avoid
- Inconsistent timing: Taking Synthroid at different times each day can lead to variable absorption and unstable hormone levels 1
- Taking with food: Food can significantly reduce the absorption of levothyroxine 1
- Switching between different brands: Different formulations may have slightly different bioavailability; maintain consistency with one brand when possible 6
- Stopping medication without consultation: Levothyroxine is typically a lifelong replacement therapy for hypothyroidism and should not be discontinued without medical advice 1