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Last updated: October 22, 2025View editorial policy

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Differential Diagnosis for Vomiting with Food

  • Single most likely diagnosis
    • Gastroesophageal reflux disease (GERD): This condition is characterized by the backflow of stomach acid into the esophagus, often triggered by eating, which can lead to vomiting. The association of vomiting with food intake is a common presentation.
  • Other Likely diagnoses
    • Food poisoning or gastroenteritis: Infections of the gastrointestinal tract can cause vomiting after eating, especially if the food consumed is contaminated.
    • Gastroparesis: A condition where the stomach takes too long to empty its contents, leading to nausea and vomiting after meals.
    • Irritable Bowel Syndrome (IBS): Although primarily associated with abdominal pain and changes in bowel habits, some individuals with IBS may experience nausea and vomiting, particularly in relation to food intake.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
    • Intestinal obstruction: A blockage in the intestines that can cause severe vomiting, especially after eating, and requires immediate medical attention.
    • Appendicitis: Inflammation of the appendix can lead to vomiting and is a surgical emergency.
    • Pancreatitis: Inflammation of the pancreas can cause severe abdominal pain and vomiting, which may be exacerbated by food intake.
  • Rare diagnoses
    • Cyclic vomiting syndrome: A rare condition characterized by recurring episodes of severe vomiting, which can be triggered by eating.
    • Rumination syndrome: A condition where food is regurgitated and then chewed and swallowed again, often accompanied by vomiting.
    • Eosinophilic esophagitis: A chronic immune system disease in which a type of white blood cell, the eosinophil, builds up in the esophagus in response to an allergen or irritant, leading to difficulty swallowing and vomiting.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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